2,4,6-Tri-tert-butyl-N-(trimethylsilyl)aniline
2,4,6-Tri-tert-butyl-N-(trimethylsilyl)aniline (CAS 101455-63-4) is a sterically hindered organic compound with the linear formula [(CH3)3C]3C6H2NHSi(CH3)3 and a molecular weight of 333.63. This protected amine serves as a valuable building block in chemical synthesis, particularly in organic chemistry research and development. Its bulky tert-butyl groups and the silyl protecting group offer unique steric and electronic properties for various synthetic transformations.
- Synonyms
- 101455-63-4, [(CH3)3C]3C6H2NHSi(CH3)3
![2,4,6-Tri-tert-butyl-N-(trimethylsilyl)aniline ([(CH3)3C]3C6H2NHSi(CH3)3) — chemical structure, CAS 101455-63-4; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F101455-63-4.png&w=3840&q=75)
Organic Synthesis Building Block
Utilised as a key intermediate in the construction of complex organic molecules. The presence of bulky tert-butyl groups and the N-trimethylsilyl protection allows for regioselective reactions and facilitates further functionalization.
Protecting Group Chemistry
The N-trimethylsilyl group acts as a protecting agent for the aniline nitrogen, enabling selective reactions on other parts of a molecule. It can be readily removed under specific conditions when required.
Sterically Hindered Amine Research
Investigated for its unique steric properties in organometallic chemistry and as a ligand in catalysis. The substantial bulk around the nitrogen atom can influence coordination geometry and reactivity.
| Molecular weight | 333.63 |
|---|---|
| Linear formula | [(CH3)3C]3C6H2NHSi(CH3)3 |
| Melting point | 86-88 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4,6-Tri-tert-butyl-N-(trimethylsilyl)aniline used for?
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This compound is primarily used as a building block in organic synthesis and for research into sterically hindered amines and protecting group chemistry.
What is the CAS number and formula for 2,4,6-Tri-tert-butyl-N-(trimethylsilyl)aniline?
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The CAS number is 101455-63-4 and its linear formula is [(CH3)3C]3C6H2NHSi(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and development purposes. The specific assay and purity are detailed in the product's Certificate of Analysis. We do not represent this product as meeting pharmacopoeial standards (USP, EP, BP).
What are the safety considerations for handling this chemical?
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This compound is classified as a Warning. It can cause skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Always handle in a well-ventilated area, wear appropriate personal protective equipment, and consult the Safety Data Sheet (SDS) before use.
Is this chemical suitable for export?
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Yes, Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, including 2,4,6-Tri-tert-butyl-N-(trimethylsilyl)aniline.
How can I request a sample or a quote?
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To request a sample or obtain a quotation, please contact our sales team directly via the website or by phone. Please specify the quantity and your delivery requirements.
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