O-(2-Mercaptoethyl)-O′-methylpolyethylene glycol
O-(2-Mercaptoethyl)-O′-methylpolyethylene glycol (CAS: 134874-49-0) is a monofunctional polyethylene glycol derivative featuring a terminal thiol group. This structure allows for specific conjugation and functionalisation in various material science applications. With an average molecular weight of 2,000 g/mol, it is commonly employed in polymer science for surface modification, bioconjugation, and the development of advanced materials where controlled attachment is required.
- IUPAC
- MeO-PEG-SH,Mercaptopolyethylene glycol monomethyl ether,PEG-thiol,Polyethylene glycol 2-mercaptoethyl methyl ether
- Synonyms
- MeO-PEG-SHMercaptopolyethylene glycol monomethyl etherPEG-thiolPolyethylene glycol 2-mercaptoethyl methyl ether

Surface Modification
This PEG derivative can be used to functionalise surfaces, altering their properties such as hydrophilicity or biocompatibility. The terminal thiol group readily reacts with activated surfaces for covalent attachment.
Bioconjugation Chemistry
The thiol functionality enables the straightforward conjugation of biomolecules to the PEG backbone. This is valuable in developing drug delivery systems and diagnostic tools.
Polymer Synthesis
It serves as a building block in polymer synthesis, allowing for the incorporation of PEG chains with specific end-group functionality into larger polymer structures or networks.
Materials Science Research
Researchers utilise this compound in the development of novel materials requiring specific surface chemistries or for creating functionalised nanoparticles and hydrogels.
| Mol Wt | average Mw 2,000 |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O-(2-Mercaptoethyl)-O′-methylpolyethylene glycol used for?
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O-(2-Mercaptoethyl)-O′-methylpolyethylene glycol is primarily used in materials science for surface modification, bioconjugation, and as a building block in polymer synthesis, particularly where specific thiol-based conjugation is needed.
What are the CAS number and molecular formula for this compound?
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The CAS number is 134874-49-0. The specific molecular formula is not provided in the data, but it is a derivative of polyethylene glycol with a defined average molecular weight.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies O-(2-Mercaptoethyl)-O′-methylpolyethylene glycol with an average Mw of 2,000 g/mol. This is a research or technical grade material and is not represented as USP, BP, or EP grade.
What are the safety and handling considerations for this chemical?
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According to the provided data, this chemical has a WGK (Germany) classification of 3, indicating it is hazardous to water. Appropriate personal protective equipment should be used, and it should be handled in a well-ventilated area. Consult the Safety Data Sheet (SDS) for comprehensive handling information.
How is this product packed, shipped, and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Product packaging and shipping methods are designed to ensure safe transport and compliance with international regulations. Specific details can be provided upon request.
How can I request a sample or quote for O-(2-Mercaptoethyl)-O′-methylpolyethylene glycol?
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To request a sample or a quotation, please contact our sales team through the website or by direct inquiry, providing the product name and CAS number (134874-49-0).
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