Ethyl 4,4,4-trifluoroacetoacetate
Ethyl 4,4,4-trifluoroacetoacetate (CAS: 372-31-6) is a fluorinated beta-keto ester with the linear formula CF3COCH2CO2C2H5 and a molecular weight of 184.11 g/mol. It serves as a versatile building block in organic synthesis, particularly for introducing trifluoromethyl groups. This compound is valuable in the development of pharmaceuticals, agrochemicals, and novel materials due to its reactive methylene group and ester functionality.
- IUPAC
- Ethyl 3-oxo-4,4,4-trifluorobutyrate
- Synonyms
- 372-31-6CF3COCH2CO2C2H5Ethyl 3-oxo-4,4,4-trifluorobutyrate
Pharmaceutical Intermediate
Utilised in the synthesis of complex fluorinated organic molecules, contributing to the development of new therapeutic agents.
Agrochemical Synthesis
A key building block for creating novel pesticides and herbicides that benefit from the unique properties imparted by the trifluoromethyl group.
Organic Synthesis Reagent
Employed in various condensation and alkylation reactions, enabling the construction of diverse chemical structures in research and development.
Material Science
Incorporated into the synthesis of specialty polymers and advanced materials where fluorination offers enhanced stability or specific properties.
| Molecular weight | 184.11 |
|---|---|
| Linear formula | CF3COCH2CO2C2H5 |
| Assay | ≥98.0% (GC) |
| Boiling point | 129-130 °C(lit.) |
| Density | 1.259 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.375(lit.)n20/D 1.376 |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H412Harmful to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 38 °C / 100.4 °F |
| Transport (UN / ADR) | UN 3272 3 / PGIII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-22-52/53 |
| Safety statements (S) | 61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl 4,4,4-trifluoroacetoacetate used for?
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Ethyl 4,4,4-trifluoroacetoacetate is primarily used as a building block in organic synthesis for pharmaceuticals, agrochemicals, and materials science, owing to its trifluoromethyl group and reactive methylene and ester functionalities.
What are the CAS number and formula for Ethyl 4,4,4-trifluoroacetoacetate?
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The CAS number is 372-31-6, and its linear formula is CF3COCH2CO2C2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl 4,4,4-trifluoroacetoacetate with an assay of ≥98.0% (GC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Ethyl 4,4,4-trifluoroacetoacetate be handled safely?
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This compound is flammable (flash point 38 °C) and harmful if swallowed, with potential long-term adverse effects in the aquatic environment. Handle with appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection. Ensure adequate ventilation and avoid release into the environment.
Is Ethyl 4,4,4-trifluoroacetoacetate a controlled substance?
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Based on the provided data, Ethyl 4,4,4-trifluoroacetoacetate is not listed as a controlled substance.
How is this chemical packed, shipped, and exported?
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This chemical is packed and shipped according to international regulations, including UN 3272 3 / PGIII. As a global supplier, Tech Serve Solutions facilitates export to various international destinations.
How can I request a sample or quote for Ethyl 4,4,4-trifluoroacetoacetate?
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To request a sample or obtain a quote, please contact our sales department through the website or by phone, providing your specific requirements.
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