Ethyl (3-methylbenzoyl)acetate
Ethyl (3-methylbenzoyl)acetate (CAS 33166-79-9) is a carbonyl compound and ester used as a building block in chemical synthesis. With a molecular weight of 206.24 g/mol, this organic compound serves as a reactant in various stereoselective reactions, including ketonization-olefination of indoles and enantioselective Michael reactions. Its properties make it a valuable intermediate for synthesizing more complex molecules.
- IUPAC
- 3-Oxo-3-(m-tolyl)propionic acid ethyl ester,Ethyl 2-(3-methylbenzoyl)acetate,Ethyl 3-oxo-3-(m-tolyl)propanoate,Ethyl 3-oxo-3-(m-tolyl)propionate,Ethyl m-methylbenzoylacetate,Ethyl m-toluoylacetate
- Synonyms
- 3-Oxo-3-(m-tolyl)propionic acid ethyl esterEthyl 2-(3-methylbenzoyl)acetateEthyl 3-oxo-3-(m-tolyl)propanoateEthyl 3-oxo-3-(m-tolyl)propionateEthyl m-methylbenzoylacetateEthyl m-toluoylacetate
Stereoselective Ketonization-Olefination
Ethyl (3-methylbenzoyl)acetate acts as a key reactant in Co/Mn-mediated oxidative cross-coupling reactions for the stereoselective ketonization-olefination of indoles, often involving dioxygen activation.
Enantioselective Michael Reactions
This compound is employed as a substrate in enantioselective Michael reactions, contributing to the synthesis of chiral molecules with high stereochemical control.
Asymmetric Hydrogenation
It serves as a reactant in SEGPhos-ruthenium-catalyzed asymmetric hydrogenation processes, enabling the synthesis of enantiomerically pure compounds.
| Molecular weight | 206.24 |
|---|---|
| Linear formula | CH3C6H4COCH2CO2CH2CH3 |
| Boiling point | 273-274 °C(lit.) |
| Density | 1.083 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5290(lit.) |
| Application | Reactant for:• Stereoselective ketonization-olefination of indoles by Co/Mn-mediated oxidative cross-coupling of indoles via dioxygen activation1• Enantioselective Michael reaction2• SEGPhos-ruthenium-catalyzed asymmetric hydrogenation3 |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl (3-methylbenzoyl)acetate used for?
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Ethyl (3-methylbenzoyl)acetate is used as a reactant in stereoselective ketonization-olefination of indoles, enantioselective Michael reactions, and SEGPhos-ruthenium-catalyzed asymmetric hydrogenation.
What is the CAS number and formula for Ethyl (3-methylbenzoyl)acetate?
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The CAS number is 33166-79-9, and its linear formula is CH3C6H4COCH2CO2CH2CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl (3-methylbenzoyl)acetate with a density of 1.083 g/mL at 25 °C and a refractive index of n20/D 1.5290. We do not represent this product as USP/BP/EP grade; it is suitable for research and general chemical synthesis purposes.
What are the safety and handling precautions for Ethyl (3-methylbenzoyl)acetate?
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As per WGK 3 (Germany), this compound requires careful handling. It is classified as hazardous and necessitates the use of eyeshields and gloves for protection. Please consult the Safety Data Sheet (SDS) for comprehensive safety information.
Is Ethyl (3-methylbenzoyl)acetate a controlled substance?
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Based on the provided data, Ethyl (3-methylbenzoyl)acetate is not listed as a controlled substance.
How is Ethyl (3-methylbenzoyl)acetate packed, shipped, and exported?
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Tech Serve Solutions professionally packs and exports chemicals globally, adhering to international shipping regulations to ensure safe and compliant delivery.
How can I request a sample or quote for Ethyl (3-methylbenzoyl)acetate?
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To request a sample or obtain a quote for Ethyl (3-methylbenzoyl)acetate, please contact our sales team through the website or by phone.
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