Ethyl (2-methylbenzoyl)acetate
Ethyl (2-methylbenzoyl)acetate (CAS: 51725-82-7) is a carbonyl compound and ester with the molecular formula C12H14O3 and a molecular weight of 206.24 g/mol. This organic building block serves as a key reactant in various synthetic organic chemistry applications, including the preparation of substituted furans and biologically active molecules like cambinol analogues. Supplied by Tech Serve Solutions with an assay of 97%, it is suitable for research and development purposes.
- IUPAC
- Ethyl 2-(2-methylbenzoyl)acetate,Ethyl 3-(2-methylphenyl)-3-oxopropanoate,Ethyl 3-oxo-3-(o-tolyl)propanoate,Ethyl o-methylbenzoylacetate,Ethyl o-toluoylacetate
- Synonyms
- Ethyl 2-(2-methylbenzoyl)acetateEthyl 3-(2-methylphenyl)-3-oxopropanoateEthyl 3-oxo-3-(o-tolyl)propanoateEthyl o-methylbenzoylacetateEthyl o-toluoylacetate
Preparation of Substituted Furans
Ethyl (2-methylbenzoyl)acetate can be utilised in tandem condensation-cyclization reactions, catalysed by bismuth triflate, for the efficient synthesis of highly substituted furan derivatives.
Co/Mn-Mediated Oxidative Cross-Coupling
This compound acts as a substrate in cobalt and manganese-mediated oxidative cross-coupling reactions, enabling complex molecular assembly.
Enantioselective Hydrogenation
It serves as a reactant in enantioselective hydrogenation processes, catalysed by ruthenium complexes, for the synthesis of chiral compounds.
Synthesis of Cambinol Analogues
Ethyl (2-methylbenzoyl)acetate is employed in the preparation of cambinol analogues, compounds investigated for their potential as sirtuin inhibitors with antitumor activity.
| Molecular weight | 206.24 |
|---|---|
| Linear formula | CH3C6H4COCH2CO2CH2CH3 |
| Assay | 97% |
| Boiling point | 256-257 °C(lit.) |
| Density | 1.069 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5255(lit.) |
| Application | Reactant for:• Preparation of highly substituted furans by tandem condensation-cyclization reactions using bismuth triflate catalyst1• Co/Mn-mediated oxidative cross-coupling2• Enantioselective ruthenium-catalyzed hydrogenation3• Preparation of cambinol analogs for sirtuin inhibition with antitumor action4 |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl (2-methylbenzoyl)acetate used for?
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Ethyl (2-methylbenzoyl)acetate is primarily used as a reactant in organic synthesis for the preparation of substituted furans, in oxidative cross-coupling reactions, enantioselective hydrogenation, and for the synthesis of biologically active molecules like cambinol analogues.
What are the CAS number and molecular formula for Ethyl (2-methylbenzoyl)acetate?
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The CAS number for Ethyl (2-methylbenzoyl)acetate is 51725-82-7, and its linear formula is CH3C6H4COCH2CO2CH2CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl (2-methylbenzoyl)acetate with a minimum assay of 97%. This product is intended for laboratory and research use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should Ethyl (2-methylbenzoyl)acetate be handled?
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Handling Ethyl (2-methylbenzoyl)acetate requires appropriate safety measures, including the use of eyeshields and gloves. It is classified under WGK Germany 3, indicating a higher hazard potential in aquatic environments.
How is Ethyl (2-methylbenzoyl)acetate packed and shipped?
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Ethyl (2-methylbenzoyl)acetate is carefully packed and exported by Tech Serve Solutions in compliance with all relevant shipping regulations for chemicals.
How can I request a sample or quote for Ethyl (2-methylbenzoyl)acetate?
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To request a sample or a quote for Ethyl (2-methylbenzoyl)acetate, please contact our sales team via the website or by phone, referencing the product name and CAS number.
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