Ethyl (2-chlorobenzoyl)acetate
Ethyl (2-chlorobenzoyl)acetate (CAS 19112-35-7) is a carbonyl compound and ester, with the linear formula ClC₆H₄COCH₂CO₂C₂H₅ and a molecular weight of 226.66 g/mol. It serves as a valuable building block in organic synthesis. Primarily utilised as a reactant in various chemical transformations, including oxidative coupling, hydrosilylation, and asymmetric hydrogenation, it is also employed in the preparation of specific heterocyclic compounds with potential applications in pharmaceuticals and agrochemicals.
- IUPAC
- Ethyl (o-chlorobenzoyl)acetate,Ethyl 3-(2-chlorophenyl)-3-oxopropanoate,NSC 158136
- Synonyms
- Ethyl 3-(2-chlorophenyl)-3-oxopropanoateNSC 158136
Cerium Ammonium Nitrate-Mediated Oxidative Coupling
Ethyl (2-chlorobenzoyl)acetate acts as a reactant in oxidative coupling reactions catalysed by cerium ammonium nitrate, enabling the formation of new carbon-carbon bonds.
Hydrosilylation Reactions
This compound is utilised as a substrate in hydrosilylation reactions, a process involving the addition of a silicon-hydride bond across an unsaturated bond.
Synthesis of Diaryl-Substituted Pyrazoles
It is a key intermediate in the preparation of diaryl-substituted pyrazoles, which have been investigated for their potential as CCR2 receptor antagonists.
Preparation of Herbicidal Agents
Ethyl (2-chlorobenzoyl)acetate is employed in the synthetic routes for compounds with potential herbicidal activity.
Ruthenium-Catalyzed Asymmetric Hydrogenation
The compound participates as a reactant in asymmetric hydrogenation processes catalysed by ruthenium, a method for chiral synthesis.
| Molecular weight | 226.66 |
|---|---|
| Linear formula | ClC6H4COCH2CO2C2H5 |
| Assay | ≥95% |
| Boiling point | 221-222 °C(lit.) |
| Density | 1.206 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.540(lit.) |
| Application | Reactant for:• Cerium ammonium nitrate-mediated oxidative coupling1• Hydrosilylation reactions2• Preparation of diaryl-substituted pyrazoles as potent CCR2 receptor antagonists3• Preparation of potential herbicidal agents4• Ruthenium-catalyzed asymmetric hydrogenation5 |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl (2-chlorobenzoyl)acetate used for?
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Ethyl (2-chlorobenzoyl)acetate is used as a reactant in various chemical syntheses, including oxidative coupling, hydrosilylation, preparation of diaryl-substituted pyrazoles, potential herbicidal agents, and ruthenium-catalyzed asymmetric hydrogenation.
What are the CAS number and formula for Ethyl (2-chlorobenzoyl)acetate?
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The CAS number is 19112-35-7 and the linear formula is ClC₆H₄COCH₂CO₂C₂H₅.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl (2-chlorobenzoyl)acetate with a minimum assay of 95%. This product is intended for research and laboratory use and is not represented as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling recommendations for Ethyl (2-chlorobenzoyl)acetate?
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For safe handling, it is recommended to use eyeshields and gloves. The compound is classified under WGK 2 in Germany, indicating it is hazardous to water. Always consult the Safety Data Sheet (SDS) before use.
How is Ethyl (2-chlorobenzoyl)acetate packed and shipped?
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Tech Serve Solutions packages and exports fine chemicals like Ethyl (2-chlorobenzoyl)acetate in compliance with international shipping regulations to ensure safe delivery worldwide.
How can I request a sample or quote for Ethyl (2-chlorobenzoyl)acetate?
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To request a sample or a quote for Ethyl (2-chlorobenzoyl)acetate, please contact our sales department through the website or by phone, providing your specific requirements.
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