Ethyl 2-chloropropionate
Ethyl 2-chloropropionate (CAS: 535-13-7), with the linear formula CH3CHClCOOC2H5 and a molecular weight of 136.58 g/mol, is a valuable ester building block. It is commonly employed in organic synthesis, particularly in the field of polymer chemistry as an initiator for controlled radical polymerization techniques. Its specific structure allows for the introduction of functional end-groups in polymer chains, enabling tailored material properties.
Polymerisation Initiator
Ethyl 2-chloropropionate serves as an effective initiator for atom transfer radical polymerisation (ATRP). It has been used in the synthesis of polymers such as poly(2-(diethylamino)ethyl methacrylate) and poly(N-isopropylacrylamide), facilitating controlled polymer chain growth.
Functionalised Polymer Synthesis
This compound is utilized in the preparation of end-functionalised polymers. For instance, it has been employed in synthesising poly(N-isopropylacrylamide) terminated with a pyrenyl group, introducing specific photophysical properties to the polymer.
Organic Synthesis Building Block
As a halogenated ester, Ethyl 2-chloropropionate is a versatile intermediate in various organic syntheses. Its reactive chlorine atom and ester functionality allow for diverse chemical transformations, making it a useful component in the construction of more complex molecules.
| Molecular weight | 136.58 |
|---|---|
| Linear formula | CH3CHClCOOC2H5 |
| Assay | 97% |
| Boiling point | 146-149 °C(lit.) |
| Density | 1.072 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.417(lit.) |
| Solubility | alcohol: misciblediethyl ether: misciblewater: insoluble |
| Application | Ethyl 2-chloropropionate was used as initiator during the synthesis of poly(2-(diethylamino)ethyl methacrylate) and poly(N-isopropylacrylamide) via atom transfer radical polymerization1. It was also used in the synthesis of end-functionalized poly(N-isopropylacrylamide) with pyrenyl group2. |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 42 °C / 107.6 °F |
| Transport (UN / ADR) | UN 2935 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl 2-chloropropionate used for?
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Ethyl 2-chloropropionate is primarily used as an initiator in atom transfer radical polymerisation (ATRP) for synthesising polymers like poly(N-isopropylacrylamide) and poly(2-(diethylamino)ethyl methacrylate), and as a building block in general organic synthesis.
What is the CAS number and formula for Ethyl 2-chloropropionate?
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The CAS number for Ethyl 2-chloropropionate is 535-13-7, and its linear formula is CH3CHClCOOC2H5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl 2-chloropropionate with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
What are the safety and handling requirements for Ethyl 2-chloropropionate?
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Ethyl 2-chloropropionate is a flammable liquid and vapour (H226), causes skin irritation (H315), causes serious eye irritation (H319), and may cause respiratory irritation (H335). It requires handling with appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, in a well-ventilated area.
How is Ethyl 2-chloropropionate packed and shipped?
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Ethyl 2-chloropropionate is packed according to industry standards for flammable liquids and shipped globally by Tech Serve Solutions, adhering to all relevant transportation regulations. It is classified under UN 2935, Class 3, Packing Group III.
How can I request a sample or quote for Ethyl 2-chloropropionate?
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To request a sample or a quote for Ethyl 2-chloropropionate, please contact our sales team via the website or direct email, providing your specific requirements.
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