Dofetilide
Dofetilide (CAS: 115256-11-6), with the molecular formula C19H27N3O5S2 and a molecular weight of 441.56 g/mol, is a bioactive small molecule. It functions as a potassium channel modulator, specifically targeting voltage-gated ion channels. This compound is recognised as an approved therapeutic/drug candidate and finds applications in cell biology and cell signaling research. Dofetilide is supplied by Tech Serve Solutions as a white to off-white powder.
- IUPAC
- N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide,UK-68798
- Synonyms
- N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide,UK-68798
Research in Cardiac Electrophysiology
Dofetilide is utilized as a pharmacological tool to study the function of specific potassium channels (IKr) in cardiac cells. Its ability to selectively block these channels aids in understanding their role in cardiac action potentials and arrhythmia mechanisms.
Development of Antiarrhythmic Therapies
As an approved therapeutic agent, Dofetilide serves as a reference compound in the development and testing of new antiarrhythmic drugs. Research may focus on refining its efficacy or exploring related compounds with improved safety profiles.
Cell Signaling and Neuroscience Studies
Beyond cardiac applications, Dofetilide can be employed in broader cell signaling research and neuroscience investigations, particularly those involving potassium channel function in neuronal tissues. This helps elucidate their contribution to neuronal excitability and function.
| Molecular weight | 441.56 |
|---|---|
| Empirical formula | C19H27N3O5S2 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | DMSO: >20 mg/mL |
| Storage temperature | room temp |
Hazard statements
- H302Harmful if swallowed
- H360May damage fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P308IF exposed or concerned
| Water hazard class (WGK, DE) | nwg |
|---|---|
| Hazard codes (EU) | T,N |
| Risk statements (R) | 61-48/22-51 |
| Safety statements (S) | 53-22-36-57 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Dofetilide used for?
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Dofetilide is used as a research tool in cardiac electrophysiology, for the development of antiarrhythmic therapies, and in studies of cell signaling and neuroscience, particularly concerning potassium channel function.
What are the CAS number and formula for Dofetilide?
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The CAS number for Dofetilide is 115256-11-6, and its molecular formula is C19H27N3O5S2.
What grade and purity does Tech Serve Solutions supply for Dofetilide?
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Tech Serve Solutions supplies Dofetilide with a purity of ≥98% as determined by HPLC. This product is intended for research purposes and is not supplied as USP, BP, EP, or any other pharmacopoeia grade.
How should Dofetilide be handled and stored?
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Dofetilide is classified with a 'Danger' signal word and carries hazard statements H302 (Harmful if swallowed) and H360 (May damage fertility or the unborn child). It should be handled with appropriate personal protective equipment in a well-ventilated area. Store at room temperature.
Is Dofetilide a controlled substance?
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The provided safety data does not indicate that Dofetilide is a controlled substance under standard regulations, though specific national or institutional controls may apply. Always check local regulations.
How is Dofetilide packed and shipped?
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Dofetilide is typically supplied as a white to off-white powder. Packaging and shipping methods comply with relevant regulations for chemical export, ensuring safe transit.
How can I request a sample or quote for Dofetilide?
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To request a sample or obtain a quote for Dofetilide, please contact the Tech Serve Solutions sales department through our official website or direct contact details, specifying the product CAS number 115256-11-6.
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