Diphenylphosphinic chloride
Diphenylphosphinic chloride (CAS 1499-21-4) is a phosphorus-containing organic compound with the linear formula (C₆H₅)₂P(O)Cl. This reagent, with a molecular weight of 236.63 g/mol, serves as a valuable building block in organic synthesis. Its primary applications include the preparation of bidentate ligands and the formation of peptide coupling agents, underscoring its utility in catalysis and complex molecule construction.
- IUPAC
- Chlorodiphenylphosphine oxide,Diphenylchlorophosphine oxide,Diphenylphosphinic acid chloride,Diphenylphosphinoyl chloride,Diphenylphosphinyl chloride,Diphenylphosphorus oxychloride,Ph2POCl
- Synonyms
- Chlorodiphenylphosphine oxideDiphenylchlorophosphine oxideDiphenylphosphinic acid chlorideDiphenylphosphinoyl chlorideDiphenylphosphinyl chlorideDiphenylphosphorus oxychloridePh2POCl
Synthesis of Bidentate Ligands
Diphenylphosphinic chloride is employed as a key intermediate in the synthesis of bidentate ligands. These ligands are crucial in coordination chemistry and homogeneous catalysis, influencing the reactivity and selectivity of metal complexes.
Peptide Coupling Reagents
This compound acts as a precursor in the development of peptide coupling agents. These reagents facilitate the formation of amide bonds, a fundamental reaction in peptide synthesis and protein chemistry.
Phosphorus Precursor
As a source of the diphenylphosphinoyl group, it is utilised in various synthetic transformations requiring the introduction of phosphorus-containing moieties into organic structures.
| Molecular weight | 236.63 |
|---|---|
| Linear formula | (C6H5)2P(O)Cl |
| Assay | 98% |
| Boiling point | 222 °C/16 mmHg(lit.) |
| Density | 1.24 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.609(lit.) |
| Storage temperature | 2-8°C |
| Application | Reagent employed in the synthesis of bidentate ligands1 and peptide coupling agents.2 |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 26 °C / 78.8 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 16-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diphenylphosphinic chloride used for?
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Diphenylphosphinic chloride is used as a reagent in the synthesis of bidentate ligands and peptide coupling agents. It also serves as a phosphorus precursor in various organic synthesis applications.
What is the CAS number and formula for Diphenylphosphinic chloride?
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The CAS number for Diphenylphosphinic chloride is 1499-21-4, and its linear formula is (C₆H₅)₂P(O)Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diphenylphosphinic chloride with a minimum assay of 98%. This product is not represented as USP, BP, or EP grade.
How should Diphenylphosphinic chloride be handled safely?
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Diphenylphosphinic chloride is a corrosive and flammable liquid. Handle with extreme care, using appropriate personal protective equipment including gloves, goggles, and a respirator. Ensure adequate ventilation and keep away from ignition sources. Refer to the Safety Data Sheet for detailed handling procedures.
How is Diphenylphosphinic chloride packed and shipped?
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Diphenylphosphinic chloride is packed and shipped according to international regulations for hazardous materials, adhering to UN 2920, Class 3(8), Packing Group II guidelines.
How can I request a sample or quote for Diphenylphosphinic chloride?
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To request a sample or a quotation for Diphenylphosphinic chloride, please contact our sales department through the TSS website or by phone.
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