Diphenylphosphine oxide
Diphenylphosphine oxide (CAS: 4559-70-0), with the linear formula (C6H5)2P(O)H and a molecular weight of 202.19 g/mol, is a key organophosphorus compound. It is primarily utilised in chemical synthesis, particularly for the preparation of triarylphosphine oxides and as a precursor for Horner-Wittig reagents. Its role extends to asymmetric catalysis, contributing to various synthetic methodologies.
- IUPAC
- HPOPh2
Preparation of Triarylphosphine Oxides
Diphenylphosphine oxide serves as a crucial intermediate in the synthesis of various triarylphosphine oxides, which are important ligands and reagents in organic chemistry.
Asymmetric Catalysis
This compound is employed as a component or precursor in the development of asymmetric catalysts, facilitating stereoselective transformations in organic synthesis.
Horner-Wittig Reagents
It is used in the preparation of alkenyldiphenylphosphine oxides, which are valuable reagents in Horner-Wittig reactions for alkene synthesis.
Ligand in Catalysis
Diphenylphosphine oxide is a precursor for ligands used in important catalytic reactions such as the Buchwald-Hartwig Cross Coupling Reaction, Hydrophosphonylations, and Suzuki-Miyaura Coupling.
| Molecular weight | 202.19 |
|---|---|
| Linear formula | (C6H5)2P(O)H |
| Assay | 97% |
| Application | Use as preparation of triarylphosphine oxides, and as asymmetric catalysts; preparation of alkenyldiphenylphosphine oxides, and Horner-Wittig reagents. |
| Melting point | 56-57 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Ligand For | Buchwald-Hartwig Cross Coupling ReactionHydrophosphonylationsSuzuki-Miyaura Coupling |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diphenylphosphine oxide used for?
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Diphenylphosphine oxide is used as a preparation for triarylphosphine oxides and as an asymmetric catalyst. It is also used for the preparation of alkenyldiphenylphosphine oxides and Horner-Wittig reagents.
What is the CAS number and formula for Diphenylphosphine oxide?
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The CAS number for Diphenylphosphine oxide is 4559-70-0, and its linear formula is (C6H5)2P(O)H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diphenylphosphine oxide with a minimum assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should Diphenylphosphine oxide be handled safely?
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Diphenylphosphine oxide is a Warning substance classified as H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment including a dust mask (type N95), eyeshields, and gloves should be used. Ensure good ventilation and avoid breathing dust.
Is Diphenylphosphine oxide a controlled substance?
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The provided data does not indicate that Diphenylphosphine oxide is a controlled substance.
How is Diphenylphosphine oxide packed and shipped?
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Products are carefully packed according to international shipping regulations. Tech Serve Solutions exports fine chemicals, pharmaceutical intermediates, and laboratory reagents globally.
How can I request a sample or quote for Diphenylphosphine oxide?
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To request a sample or obtain a quote for Diphenylphosphine oxide, please contact our sales team through the website or by phone.
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