(Dimethylamino)sulfur trifluoride
(Dimethylamino)sulfur trifluoride (CAS: 3880-03-3), with the linear formula (CH3)2NSF3 and a molecular weight of 133.14 g/mol, is a potent fluorinating agent. It is highly effective in organic synthesis for the introduction of fluorine atoms into various organic molecules. This reagent is particularly valuable for the conversion of alcohols, aldehydes, and ketones into their corresponding fluorinated derivatives, making it an essential tool in synthetic chemistry laboratories.
- IUPAC
- Methyl DAST
- Synonyms
- DASTMethyl DAST
Fluorination of Alcohols, Aldehydes, and Ketones
DAST serves as a versatile reagent for converting hydroxyl groups in alcohols to fluorine atoms. It can also be used for the fluorodeoxygenation of aldehydes and ketones, replacing the carbonyl oxygen with two fluorine atoms.
Synthesis of Fluorinated Compounds
This reagent is employed in the preparation of fluorinated analogues of biologically active molecules, such as fluorinated podophyllotoxin derivatives, which are of interest in medicinal chemistry research.
Preparation of Glycosyl Fluorides
DAST enables the conversion of protected thioglycosides into valuable glycosyl fluorides, which are important building blocks in carbohydrate chemistry and glycobiology.
| Molecular weight | 133.14 |
|---|---|
| Linear formula | (CH3)2NSF3 |
| Boiling point | 117.5 °C(lit.) |
| Density | 1.364 g/mL at 25 °C(lit.) |
| Storage temperature | 2-8°C |
| Application | Fluorinating Agent used in the fluorination of compounds such as• Alchols, aldehydes and ketones1• Fluorinated Podophyllotoxin derivatives2• Protected glycosyl fluorides from thioglycosides3 |
| Melting point | −78.7 °C(lit.) |
Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H314Causes severe skin burns and eye damage
- H332Harmful if inhaled
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 9 °C / 48.2 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-20/21/22-35 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Dimethylamino)sulfur trifluoride primarily used for?
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(Dimethylamino)sulfur trifluoride (DAST) is primarily used as a fluorinating agent in organic synthesis, particularly for the conversion of alcohols, aldehydes, and ketones to their fluorinated counterparts.
What is the CAS number and chemical formula for (Dimethylamino)sulfur trifluoride?
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The CAS number for (Dimethylamino)sulfur trifluoride is 3880-03-3 and its linear chemical formula is (CH3)2NSF3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (Dimethylamino)sulfur trifluoride as a technical or research grade reagent. We do not represent it as USP, BP, EP, or any other pharmacopoeial grade unless explicitly stated in the product specifications.
What are the main safety hazards associated with (Dimethylamino)sulfur trifluoride?
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(Dimethylamino)sulfur trifluoride is a highly hazardous substance. It is flammable (H225), harmful if swallowed (H302), harmful in contact with skin (H312), causes severe skin burns and eye damage (H314), and harmful if inhaled (H332). Appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, must be used. It must be handled with extreme caution in a well-ventilated area.
How is (Dimethylamino)sulfur trifluoride packed, shipped, and exported?
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Information regarding specific packing, shipping, and export details for (Dimethylamino)sulfur trifluoride can be obtained by contacting our sales department directly. It is classified under UN 2920.
How can I request a sample or quote for (Dimethylamino)sulfur trifluoride?
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To request a sample or a quotation for (Dimethylamino)sulfur trifluoride, please contact our sales team via the 'Contact Us' section of our website or by calling our customer service number.
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