Digitonin
Digitonin (CAS: 11024-24-1; Formula: C56H92O29) is a complex saponin with a molecular weight of 1229.31 g/mol. This mild nonionic detergent is known for its ability to solubilise receptors and permeabilise cellular and nuclear membranes. It finds application in various biological research areas, including cell biology, cell lysis, and the study of cell signalling. Its properties make it a valuable reagent for biochemical investigations.
- IUPAC
- Digitin
Mitochondrial Isolation
Digitonin has been utilised in research to facilitate the isolation of mitochondria from specific cell types, such as ascites tumour cells, by aiding in the procedural steps.
Membrane Permeabilisation
As a mild nonionic detergent, digitonin can effectively permeabilise cellular and nuclear membranes, making it useful for studies requiring access to intracellular components.
Receptor Solubilisation
This compound is capable of solubilising receptors, which is crucial for biochemical and biophysical studies investigating receptor function and interactions within cell membranes.
Cytotoxicity Studies
Digitonin has been employed in studies to assess its influence on the cytotoxicity of various compounds, such as plant secondary metabolites, within cancer cell lines.
| Molecular weight | 1229.31 |
|---|---|
| Empirical formula | C56H92O29 |
| Solubility | H2O: ~5 % (w/v) (solubilized by heating to 95 °C - 98 °C and then cooling to room temp.) |
| Optical activity | [α]20/D −54°, c = 2.8 in methanol(lit.) |
| Application | Digitonin has been used in a study to assess a procedure for isolating mitochondria from ascites tumor cells. 1 It has also been used in a study to investigate its effect on the cytotoxicity of plant secondary metabolites in cancer cells. 2 This mild nonionic detergent can be used to solubilize receptors and permeabilize cellular and nuclear membranes. |
| Melting point | 230-240 °C (dec.)(lit.) |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3462 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25 |
| Safety statements (S) | 22-28-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Mol Wt | micellar avg mol wt 70,000 |
|---|---|
| Aggregation Number | 60 |
| Cmc | <0.5 mM(20-25°C) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Digitonin used for?
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Digitonin is used for solubilising receptors and permeabilising cellular and nuclear membranes in biological research. It has also been applied in studies involving mitochondrial isolation and the assessment of cytotoxicity.
What are the CAS number and formula for Digitonin?
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The CAS number for Digitonin is 11024-24-1, and its empirical formula (Hill notation) is C56H92O29.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Digitonin as a technical/research grade chemical. We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade unless explicitly stated otherwise in the product specifications.
How should Digitonin be handled safely?
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Digitonin is classified as dangerous. It is toxic if swallowed, toxic in contact with skin, and toxic if inhaled (H301-H311-H330). Always use appropriate personal protective equipment, including eyeshields, face shields, gloves, and a P2 respirator if necessary. Handle in a well-ventilated area and avoid dust formation.
Is Digitonin a controlled substance?
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The provided data does not indicate that Digitonin is a controlled substance.
How is Digitonin packed, shipped, and exported?
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Digitonin is packed and shipped in compliance with relevant regulations for hazardous materials. As a global supplier, Tech Serve Solutions has extensive experience in exporting chemicals worldwide.
How can I request a sample or quote for Digitonin?
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To request a sample or a quote for Digitonin, please contact our sales team via the details provided on our website.
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