Diethyl(3-pyridyl)borane
Diethyl(3-pyridyl)borane (CAS: 89878-14-8), with the molecular formula C9H14BN and a molecular weight of 147.03 g/mol, is a borane derivative crucial for various synthetic applications. This compound serves as a key reactant in complex organic syntheses, including the preparation of potential anticancer agents and in palladium-catalyzed cross-coupling reactions. Its utility extends to N-methylation and the synthesis of heterocyclic compounds.
- IUPAC
- 3-(Diethylboryl)pyridine
- Synonyms
- 3-(Diethylboryl)pyridine
Preparation of Anticancer Agents
Utilised as a reactant in the preparation of inhibitors targeting ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase, which are investigated as potential anticancer agents.
N-Methylation of Pyridyl Groups
Functions as a reagent in N-methylation reactions, specifically modifying the pyridyl group within a molecule.
Palladium-Catalyzed Reactions
Employed in palladium-catalyzed amination reactions and coupling reactions, facilitating the formation of new carbon-nitrogen and carbon-carbon bonds.
Heck Reactions
Serves as a reactant in intramolecular Heck reactions, a powerful tool for forming cyclic organic structures.
Pyrimidine Synthesis
Used in Suzuki coupling reactions for the synthesis of trisubstituted pyrimidines, starting from polyhalopyrimidines.
| Molecular weight | 147.03 |
|---|---|
| Empirical formula | C9H14BN |
| Assay | 97% |
| Application | Reactant for:• Preparation of inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents1• N-Methylation reactions of the pyridyl group2• Palladium catalyzed amination reactions3• Intramolecular Heck reactions4• Coupling reactions5• Synthesis of trisubstituted pyrimidines from polyhalopyrimidines via Suzuki coupling6 |
| Melting point | 172-175 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diethyl(3-pyridyl)borane used for?
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Diethyl(3-pyridyl)borane is used as a reactant in various organic syntheses, including the preparation of potential anticancer agents, N-methylation reactions, palladium-catalyzed amination and coupling reactions, intramolecular Heck reactions, and the synthesis of trisubstituted pyrimidines.
What are the CAS number and formula for Diethyl(3-pyridyl)borane?
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The CAS number is 89878-14-8 and the empirical formula is C9H14BN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diethyl(3-pyridyl)borane with an assay of 97%. We do not represent this product as USP, BP, EP or other pharmacopoeia grades.
How should Diethyl(3-pyridyl)borane be handled safely?
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Diethyl(3-pyridyl)borane is classified as a Warning. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area.
How is Diethyl(3-pyridyl)borane packed and shipped?
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Diethyl(3-pyridyl)borane is supplied according to standard chemical packaging procedures and is available for global export.
How can I request a quote or sample?
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Please contact our sales team via the website or direct email to request a quotation or a sample of Diethyl(3-pyridyl)borane.
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