Diallyl N,N-diisopropylphosphoramidite
Diallyl N,N-diisopropylphosphoramidite (CAS 126429-21-8) is a valuable phosphorus-containing organic building block. With a molecular weight of 245.30 g/mol, it serves as a key precursor in complex organic synthesis. Its applications are primarily within the pharmaceutical and fine chemical industries, facilitating the creation of novel molecules with potential therapeutic activities.
- IUPAC
- N,N-Bis(1-methylethyl)phosphoramidous acid di-2-propenyl ester,Diallyloxy(diisopropylamino)phosphine
- Synonyms
- [(CH3)2CH]2NP(OCH2CH=CH2)2N,N-Bis(1-methylethyl)phosphoramidous acid di-2-propenyl esterDiallyloxy(diisopropylamino)phosphine
![Diallyl N,N-diisopropylphosphoramidite ([(CH3)2CH]2NP(OCH2CH=CH2)2) — chemical structure, CAS 126429-21-8; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F126429-21-8.png&w=3840&q=75)
Synthesis of S1P1 Agonists
This compound is utilised as a precursor in the synthesis of selective, orally active S1P1 agonists, which are investigational agents for various medical conditions.
Antifungal Prodrug Development
It plays a role in the creation of water-soluble prodrugs of triazole CS-758, a compound investigated for its antifungal properties.
Antitumor Agent Analogues
Diallyl N,N-diisopropylphosphoramidite is involved in synthesising fostriecin analogues, which are explored for their potential as antitumor agents.
Phosphitylation Reactions
The reagent is employed in phosphitylation reactions of alcohols and for the stereoselective Pudovik rearrangement in organic synthesis.
Nucleoside Phosphoramidite Synthesis
It is used in deallylation processes, a critical step in the synthesis of nucleoside phosphoramidites, important in oligonucleotide chemistry.
| Molecular weight | 245.30 |
|---|---|
| Linear formula | [(CH3)2CH]2NP(OCH2CH=CH2)2 |
| Boiling point | 130 °C(lit.) |
| Density | 0.928 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.456(lit.) |
| Storage temperature | 2-8°C |
| Application | Precursor involved in the synthesis of pharmacologically active molecules including:• Selective orally active S1P1 agonists1• Water-soluble prodrugs of triazole CS-758 with antifungal activity2• Fostriecin analogs as antitumor agents3Reactant involved in: • Phosphitylation of alcohols4• Deallylation for the synthesis of nucleoside phosphoramidite5• Posphitylation and stereoselective Pudovik rearrangement6 |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 32 °C / 89.6 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diallyl N,N-diisopropylphosphoramidite used for?
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Diallyl N,N-diisopropylphosphoramidite is primarily used as a precursor in the synthesis of pharmacologically active molecules, including selective S1P1 agonists, antifungal agents, and antitumor compounds. It also serves as a reactant in phosphitylation of alcohols and deallylation for nucleoside phosphoramidite synthesis.
What are the CAS number and formula for Diallyl N,N-diisopropylphosphoramidite?
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The CAS number is 126429-21-8. The linear formula is [(CH3)2CH]2NP(OCH2CH=CH2)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical as a research or technical grade material. We do not represent it as USP, BP, EP, or any other pharmacopoeial grade unless explicitly stated in the product specifications.
How should Diallyl N,N-diisopropylphosphoramidite be handled safely?
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This compound is flammable and can cause skin, eye, and respiratory irritation (H226-H315-H319-H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Ensure good ventilation.
Is this chemical suitable for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents.
How can I request a quote or sample?
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Please contact our sales team through the website to request a quote or a sample of Diallyl N,N-diisopropylphosphoramidite.
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