(DHQD)2PHAL

CAS 140853-10-7C48H54N6O4Chemical Synthesis

(DHQD)2PHAL (CAS: 140853-10-7) is a chiral ligand derived from hydroquinidine. With the molecular formula C48H54N6O4 and a molecular weight of 778.98 g/mol, it is a key reagent in asymmetric synthesis. Its primary application is as a ligand in the Sharpless asymmetric dihydroxylation reaction, enabling the enantioselective synthesis of vicinal diols from olefins. This compound is supplied by Tech Serve Solutions for advanced chemical research and development.

IUPAC: Hydroquinidine 1,4-phthalazinediyl diether

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(DHQD)2PHAL (C48H54N6O4) — chemical structure, CAS 140853-10-7; Chemistry, fine chemical supplied by Tech Serve Solutions

Asymmetric SynthesisChemical SynthesisChiral CatalystsLigandsand ReagentsCinchona AlkaloidsDihydroxylation

01 /Applications

Sharpless Asymmetric Dihydroxylation Ligand

This hydroquinidine derivative serves as a critical chiral ligand in the Nobel Prize-winning Sharpless Asymmetric Dihydroxylation (AD) reaction. It facilitates the highly enantioselective conversion of alkenes to chiral vicinal diols, which are valuable synthetic intermediates.

Chiral Catalyst Component

As a component of chiral catalytic systems, (DHQD)2PHAL is instrumental in promoting stereoselective transformations. Its well-defined structure and efficacy make it a preferred choice for researchers aiming for high enantiomeric excesses in complex molecule synthesis.

Asymmetric Synthesis Reagent

Beyond dihydroxylation, this privileged ligand finds use in other asymmetric reactions where stereocontrol is paramount. Its applicability extends to various fields requiring enantiomerically pure compounds, including pharmaceuticals and fine chemicals.

02 /Properties

Molecular weight	778.98
Empirical formula	C48H54N6O4
Assay	≥95%
Optical activity	[α]22/D −262°, c = 1.2 in methanol
Application	Ligand for Sharpless Asymmetric Dihydroxylation.
Melting point	160 °C (dec.)(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

140853-10-7

MDL number

MFCD00198107

PubChem substance

24864481

Beilstein registry

5475678

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (DHQD)2PHAL primarily used for?

This compound is principally used as a chiral ligand in the Sharpless asymmetric dihydroxylation reaction for the enantioselective synthesis of vicinal diols.

What is the CAS number and molecular formula for (DHQD)2PHAL?

The CAS number is 140853-10-7, and the molecular formula is C48H54N6O4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies (DHQD)2PHAL with an assay of ≥95%. This product is intended for research and development purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.

What are the main safety considerations when handling (DHQD)2PHAL?

Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. The compound has a WGK Germany rating of 3, indicating it is hazardous to water.

How is (DHQD)2PHAL typically shipped or exported by TSS?

Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and reagents, ensuring appropriate packaging and documentation for international shipments of (DHQD)2PHAL.