Dexrazoxane
Dexrazoxane (CAS: 24584-09-6, C11H16N4O4) is a synthetic organic compound with a molecular weight of 268.27 g/mol. Supplied as a white to off-white powder, it functions primarily as a cardioprotective agent, mitigating the cardiotoxic effects of anthracycline chemotherapy. Its mechanism involves chelating iron, thereby preventing the formation of reactive oxygen species that damage heart muscle cells. This makes it a critical adjunct in certain cancer treatment regimens.
- IUPAC
- (+)-(S)-4,4′-Propylenedi-2,6-piperazinedione,(S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane,Cardioxane,ICRF-187,NSC169780,Zinecard
- Synonyms
- (+)-(S)-4,4′-Propylenedi-2,6-piperazinedione(S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propaneCardioxaneICRF-187NSC169780Zinecard
Cardiomyopathy Prevention
Dexrazoxane is administered to reduce the incidence and severity of doxorubicin-induced cardiomyopathy. It acts by chelating intracellular iron, thus preventing the generation of free radicals responsible for myocardial damage during anthracycline therapy.
Chemotherapy Adjunct
As an adjunct to chemotherapy, particularly with anthracyclines like doxorubicin and daunorubicin, Dexrazoxane helps preserve cardiac function. This allows for the continuation of necessary cancer treatment with reduced risk of heart failure.
Research Chemical
This compound is utilised in research settings to study mechanisms of iron chelation, oxidative stress, and DNA repair. Its role in cellular defence against drug-induced toxicity is of significant interest in biomedical research.
| Molecular weight | 268.27 |
|---|---|
| Empirical formula | C11H16N4O4 |
| Assay | ≥95% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | DMSO: >20 mg/mL |
| Storage temperature | room temp |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Dexrazoxane used for?
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Dexrazoxane is primarily used as a cardioprotective agent to mitigate the cardiotoxic effects of anthracycline chemotherapy, preventing doxorubicin-induced cardiomyopathy. It is also used in research to study iron chelation and cellular defence mechanisms.
What are the CAS number and formula for Dexrazoxane?
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The CAS number for Dexrazoxane is 24584-09-6, and its empirical formula is C11H16N4O4.
What grade and purity does Tech Serve Solutions supply for Dexrazoxane?
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Tech Serve Solutions supplies Dexrazoxane with an assay of ≥95% (HPLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade unless explicitly stated in the product specifications.
How should Dexrazoxane be handled safely?
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Dexrazoxane is classified as a Warning hazard (GHS07) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment in a well-ventilated area, avoiding dust formation and contact with skin, eyes, and clothing. Refer to the Safety Data Sheet for detailed information.
How is Dexrazoxane packaged and shipped?
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Dexrazoxane is typically supplied as a powder and is stored at room temperature. For export inquiries and specific packaging requirements, please contact our sales team.
How can I request a sample or quote for Dexrazoxane?
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To request a sample or a quotation for Dexrazoxane, please contact the Tech Serve Solutions sales department via our website or direct contact information.
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