DAPT

CAS 208255-80-5C23H26F2N2O4Biochemicals & Reagents

DAPT (CAS: 208255-80-5; C23H26F2N2O4) is a white, solid organic compound with a molecular weight of 432.46 g/mol. This chemical functions as a potent gamma-secretase inhibitor. It is recognised for its utility in biochemical research, particularly in cell biology and neuroscience, where it aids in understanding cellular processes and signaling pathways.

IUPAC: GSI-IX,LY-374973,N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
Synonyms: N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl esterGSI-IXLY-374973

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DAPT (C23H26F2N2O4) — chemical structure, CAS 208255-80-5; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyD-DIFEli LillyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand Substrates

01 /Applications

Gamma-Secretase Inhibition

DAPT serves as a research tool to inhibit gamma-secretase activity. This inhibition is crucial for studying the Notch signaling pathway, which plays a role in cell differentiation, proliferation, and apoptosis.

Neuroscience Research

In neuroscience, DAPT is employed to investigate the role of gamma-secretase in neurological disorders. Its ability to modulate amyloid precursor protein (APP) processing is relevant to Alzheimer's disease research.

Cell Biology Studies

As a bioactive small molecule, DAPT is utilized in cell biology to explore fundamental cellular mechanisms. It helps researchers probe signaling cascades and understand protein processing within cells.

02 /Properties

Molecular weight	432.46
Empirical formula	C23H26F2N2O4
Assay	≥98% (HPLC)
Form	solid
Colour	white
Solubility	DMSO: ~18 mg/mL
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

208255-80-5

MDL number

MFCD04974585

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is DAPT primarily used for?

DAPT is primarily used as a gamma-secretase inhibitor in research settings, particularly in cell biology and neuroscience to study pathways such as Notch signaling and amyloid precursor protein processing.

What are the CAS number and formula for DAPT?

The CAS number for DAPT is 208255-80-5, and its empirical formula is C23H26F2N2O4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies DAPT with a minimum purity of ≥98% (HPLC). This product is intended for research and laboratory use only and is not supplied as USP, BP, EP, or any other pharmacopoeia grade.

How should DAPT be handled and stored?

DAPT is a solid compound that should be handled with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator filter (type N95 or P1). It should be stored at 2-8°C.

How is DAPT shipped and exported?

DAPT is carefully packed and shipped by Tech Serve Solutions, adhering to all relevant regulations for the export of chemical compounds, ensuring safe and compliant delivery worldwide.