Cyclobutylboronic acid
Cyclobutylboronic acid (CAS: 849052-26-2) is an organoboron compound with the formula C4H9BO2. This versatile reagent is primarily employed in organic synthesis, particularly in palladium-catalyzed cross-coupling reactions. Its structure facilitates the introduction of the cyclobutyl moiety into various organic frameworks, making it valuable for the construction of complex molecules in pharmaceutical and materials science research.
Suzuki-Miyaura Cross-Coupling
Used in palladium-catalyzed Suzuki-Miyaura cross-coupling reactions for the synthesis of cyclobutyl arenes and heteroarenes from potassium cyclobutyltrifluoroborate intermediates and aryl/heteroaryl chlorides.
C-H Activation and Arylation
Acts as a reagent in the palladium-catalyzed arylation of diphenylisoxazole, utilising C-H activated isoxazole palladacycle intermediates.
Organic Synthesis Reagent
A key building block in organic chemistry for introducing cyclobutyl groups into target molecules, facilitating the creation of novel chemical entities.
| Molecular weight | 99.92 |
|---|---|
| Empirical formula | C4H9BO2 |
| Assay | ≥95.0% |
| Storage temperature | 2-8°C |
| Application | • Reagent used in palladium-catalyzed arylation and alkylation of diphenylisoxazole with boronic acids via C-H activated isoxazole palladacycle intermediate • Reagent used in the preparation of cyclobutyl arenes and heteroarenes via palladium catalyzed Suzuki-Miyaura cross-coupling reaction of potassium cyclobutyltrifluoroborate intermediate with aryl and heteroaryl chlorides |
| Melting point | 118-123 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Cyclobutylboronic acid used for?
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Cyclobutylboronic acid is used as a reagent in palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction, to introduce cyclobutyl groups into organic molecules. It is also employed in C-H activation and arylation processes.
What is the CAS number and formula for Cyclobutylboronic acid?
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The CAS number for Cyclobutylboronic acid is 849052-26-2, and its empirical formula is C4H9BO2.
What is the purity of Cyclobutylboronic acid supplied by TSS?
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Cyclobutylboronic acid is supplied by TSS with an assay of ≥95.0%.
What are the main hazards associated with Cyclobutylboronic acid?
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Cyclobutylboronic acid is classified under GHS07, indicating potential skin irritation, serious eye irritation, and respiratory tract irritation. Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, should be used.
How is Cyclobutylboronic acid shipped and exported?
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Tech Serve Solutions (TSS) is a specialist global supplier and exporter, capable of packing and shipping chemicals like Cyclobutylboronic acid according to international regulations.
How can I request a quote for Cyclobutylboronic acid?
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To request a quote for Cyclobutylboronic acid, please contact our sales team through the TSS website or by phone, providing your required quantity and delivery details.
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