Cyclobutane-1,2,3,4-tetracarboxylic dianhydride
Cyclobutane-1,2,3,4-tetracarboxylic dianhydride (CAS: 4415-87-6), with the molecular formula C8H4O6 and a molecular weight of 196.11 g/mol, is a key organic building block. This compound serves as a precursor in the synthesis of advanced materials, notably polyimide films and poly(amic acid) derivatives used in liquid crystal alignment layers. Its rigid cyclobutane core imparts unique properties to polymers derived from it, making it valuable in specialised chemical synthesis.
- IUPAC
- 1,2,3,4-Cyclobutanetetracarboxylic dianhydride,Cyclobutanetetracarboxylic acid dianhydride,Cyclobutanetetracarboxylic dianhydride,Maleic anhydride cyclic dimer
- Synonyms
- 1,2,3,4-Cyclobutanetetracarboxylic dianhydrideCyclobutanetetracarboxylic acid dianhydrideCyclobutanetetracarboxylic dianhydrideMaleic anhydride cyclic dimer

Polyimide Film Synthesis
Cyclobutane-1,2,3,4-tetracarboxylic dianhydride is employed in the production of high-performance polyimide films. These materials are known for their thermal stability and mechanical strength.
Liquid Crystal Alignment Layers
It is used to synthesise poly(amic acid) polymers which function as alignment layers in liquid crystal displays. This application leverages the molecule's structure to influence the orientation of liquid crystals.
Organic Synthesis Intermediate
As a versatile building block, this dianhydride is utilised in various organic synthesis pathways for creating complex molecules and functional polymers.
| Molecular weight | 196.11 |
|---|---|
| Empirical formula | C8H4O6 |
| Assay | ≥94% |
| Application | Cyclobutane-1,2,3,4-tetracarboxylic dianhydride was used to synthesize polyimide films1 and poly(amic acid) having liquid crystal alignment layers2. |
| Melting point | >300 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Cyclobutane-1,2,3,4-tetracarboxylic dianhydride used for?
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It is used in the synthesis of polyimide films and poly(amic acid) having liquid crystal alignment layers, and serves as a general building block in organic synthesis.
What are the CAS number and molecular formula for Cyclobutane-1,2,3,4-tetracarboxylic dianhydride?
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The CAS number is 4415-87-6, and the molecular formula is C8H4O6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Cyclobutane-1,2,3,4-tetracarboxylic dianhydride with an assay of ≥94%. We do not represent this product as USP, BP, or EP grade.
What are the main hazards associated with this chemical?
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This compound is a warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used during handling.
How is Cyclobutane-1,2,3,4-tetracarboxylic dianhydride packed and exported?
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As a global supplier, Tech Serve Solutions expertly packs and exports chemicals worldwide, ensuring compliance with international shipping regulations. Specific packaging details are available upon request.
How can I request a quote or sample?
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To request a quote or sample of Cyclobutane-1,2,3,4-tetracarboxylic dianhydride, please contact our sales team via the website or by phone.
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