α-Cyano-4-hydroxycinnamic acid
α-Cyano-4-hydroxycinnamic acid (CAS: 28166-41-8), with the molecular formula HOC6H4CH=C(CN)CO2H and a molecular weight of 189.17 g/mol, is a valuable organic compound. It serves as a matrix in mass spectrometry for analysing peptides and nucleotides, and is also utilised in chemical synthesis and cell biology research. This compound is supplied by Tech Serve Solutions.
- IUPAC
- α-CCA,α-CHCA,α-Cyano,4-HCCA,ACCA,alpha-Cyano-4-hydroxycinnamic acid
- Synonyms
- α-CCAα-CHCAα-Cyano4-HCCAACCAalpha-Cyano-4-hydroxycinnamic acid
Matrix for Mass Spectrometry
α-Cyano-4-hydroxycinnamic acid (CHC) functions as an effective matrix for the mass spectroscopic analysis of peptides and nucleotides, aiding in their ionisation and detection.
Encapsulation Research
This compound has been investigated for its use in encapsulation processes, specifically in the context of incorporating CHC into NaY zeolite structures.
Angiogenesis Assays
CHC is employed as a matrix to facilitate the investigation of paclitaxel derivative activity through in vitro angiogenesis assays, contributing to biochemical research.
Chemical Synthesis Building Block
As an organic building block, α-Cyano-4-hydroxycinnamic acid is useful in the synthesis of more complex molecules within the chemical and pharmaceutical industries.
| Molecular weight | 189.17 |
|---|---|
| Linear formula | HOC6H4CH=C(CN)CO2H |
| Assay | 97% |
| Solubility | methanol: soluble50 mg/mL, clear to slightly hazy, light yellow to yellow |
| Storage temperature | 2-8°C |
| Application | α-Cyano-4-hydroxycinnamic acid(CHC) was used as a matrix for peptides1 and nucleotides2 in mass spectroscopic analysis. It was used in encapsulation of CHC into NaY zeolite3. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays4. |
| Melting point | 245-250 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Analyte Suitability | glycanspeptidesproteins |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is α-Cyano-4-hydroxycinnamic acid used for?
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α-Cyano-4-hydroxycinnamic acid is primarily used as a matrix in mass spectrometry for peptides and nucleotides, in encapsulation research, and for investigating angiogenesis assays. It also serves as a building block in chemical synthesis.
What are the CAS number and formula for α-Cyano-4-hydroxycinnamic acid?
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The CAS number is 28166-41-8 and the linear formula is HOC6H4CH=C(CN)CO2H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies α-Cyano-4-hydroxycinnamic acid with an assay of 97%. TSS does not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for this chemical?
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This compound is classified with GHS07 symbol and 'Warning' signal word. It carries hazard statements H315, H319, and H335, indicating it causes skin irritation, serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, should be used. Store at 2-8°C.
How is this product typically packed, shipped, and exported?
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Tech Serve Solutions packs and ships fine chemicals, laboratory reagents, and pharmaceutical intermediates globally. Specific packaging details are available upon request.
How can I request a sample or a quote for α-Cyano-4-hydroxycinnamic acid?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team through our official website or provided contact channels.
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