CPhos

CAS 1160556-64-8C28H41N2PCatalysis & Inorganic

CPhos (CAS: 1160556-64-8), a complex organophosphorus compound with the formula C28H41N2P and a molecular weight of 436.61 g/mol, is a specialised phosphine ligand. It plays a crucial role as a catalyst or ligand in various organic synthesis reactions, particularly in cross-coupling methodologies. Its unique structure facilitates efficient catalytic cycles in chemical research and development settings.

IUPAC: 2-Dicyclohexylphosphino-2′,6′-bis(N,N-dimethylamino)biphenyl

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CPhos (C28H41N2P) — chemical structure, CAS 1160556-64-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Buchwald LigandsChemical SynthesisCross-CouplingPhosphine CompoundsPhosphine Ligands More...

01 /Applications

Cross-Coupling Reactions

CPhos serves as an effective ligand in palladium-catalysed cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig amination, and Sonogashira couplings. Its steric and electronic properties promote high yields and selectivity in the formation of carbon-carbon and carbon-heteroatom bonds.

Homogeneous Catalysis

As a phosphine ligand, CPhos is employed in homogeneous catalysis to stabilise and activate metal centres. This enables a variety of transformations in organic synthesis, contributing to the development of new synthetic routes for complex molecules.

Pharmaceutical Intermediate Synthesis

The compound is utilised in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs). Its application in efficient coupling reactions aids in constructing intricate molecular architectures required for drug discovery and manufacturing.

02 /Properties

Molecular weight	436.61
Empirical formula	C28H41N2P
Assay	98%
Melting point	108-113 °C

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

1160556-64-8

MDL number

MFCD27978504

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is CPhos primarily used for?

CPhos is primarily used as a phosphine ligand in palladium-catalyzed cross-coupling reactions and other homogeneous catalysis applications within organic synthesis.

What are the CAS number and chemical formula for CPhos?

The CAS number for CPhos is 1160556-64-8, and its chemical formula is C28H41N2P.

What grade and purity does Tech Serve Solutions supply for CPhos?

Tech Serve Solutions supplies CPhos with an assay of 98%. We do not represent this product as USP, BP, or EP grade.

How should CPhos be handled and stored safely?

CPhos is a Warning substance that may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment in a well-ventilated area. Avoid breathing dust/fume/gas/mist/vapours/spray. If in eyes, rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Avoid prolonged or repeated exposure.