Concanamycin A
Concanamycin A (CAS: 80890-47-7, C46H75NO14, MW: 866.09) is a potent and selective inhibitor of vacuolar-type H+-ATPase (V-ATPase). This macrolide antibiotic exhibits potent biological activity, primarily utilised in research settings for its ability to disrupt lysosomal acidification and cellular protein degradation pathways. It serves as a critical tool in cellular biology and biochemical studies, aiding investigations into cellular transport and function.
- IUPAC
- Folimycin
V-ATPase Inhibition
Concanamycin A is a widely recognised inhibitor of vacuolar-type H+-ATPase (V-ATPase). It is extensively used in research to probe the function of V-ATPase in various cellular processes, including protein degradation, receptor trafficking, and phagosome maturation.
Cellular Biology Research
Its ability to block V-ATPase makes Concanamycin A invaluable for studying cellular acidification, lysosomal function, and autophagy. Researchers employ it to investigate the roles of these processes in disease mechanisms and cellular homeostasis.
Biochemical Assays
Concanamycin A serves as a standard reagent in biochemical assays investigating enzyme activity and cellular signaling pathways influenced by proton gradients. Its high specificity allows for precise experimental manipulation.
| Molecular weight | 866.09 |
|---|---|
| Empirical formula | C46H75NO14 |
| Assay | ≥70% (HPLC) |
| Storage temperature | −20°C |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H319Causes serious eye irritation
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P302IF ON SKIN
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3462 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28-36 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Concanamycin A used for?
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Concanamycin A is primarily used as a potent and selective inhibitor of vacuolar-type H+-ATPase (V-ATPase) in biochemical and cellular biology research. It is employed to study cellular acidification, protein degradation pathways, autophagy, and receptor trafficking.
What is the CAS number and formula for Concanamycin A?
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The CAS number for Concanamycin A is 80890-47-7, and its empirical formula is C46H75NO14.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Concanamycin A with a purity of ≥70% (HPLC). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeial grade.
How should Concanamycin A be handled safely?
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Concanamycin A is a dangerous substance marked with GHS06 and the signal word Danger. It carries hazard statements H300 (Fatal if swallowed), H310 (Fatal in contact with skin), H319 (Causes serious eye irritation), and H330 (Fatal if inhaled). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges, must be used during handling.
Is Concanamycin A a controlled substance?
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The provided data does not indicate that Concanamycin A is a controlled substance.
How is Concanamycin A shipped and exported?
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Concanamycin A is shipped as UN 3462, Hazard Class 6.1, Packing Group II. Tech Serve Solutions, a specialist global supplier and exporter, handles all logistical requirements for its international distribution.
How can I request a quote or sample for Concanamycin A?
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To request a quote or sample of Concanamycin A, please contact our sales department through the TSS website or by telephone. Our team will be pleased to assist with your inquiry.
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