Concanamycin C from Streptomyces sp.
Concanamycin C (CAS: 81552-34-3), a macrolide antibiotic with formula C45H74O13 and molecular weight 823.06, is supplied by Tech Serve Solutions. This compound acts as a potent inhibitor of vacuolar-type H+-ATPase (V-ATPase) enzymes. It is primarily utilised in research to investigate cellular processes, including the suppression of antigen presentation by MHC class II molecules and the functional roles of V-ATPases in eukaryotic organelle acidification.
Inhibition of V-ATPase Activity
Concanamycin C is a well-established inhibitor of vacuolar-type H+-ATPase (V-ATPase). This makes it a valuable tool for studying the physiological roles of V-ATPases in cellular functions such as endosomal and lysosomal acidification.
Immunology Research
This compound can be employed to suppress antigen presentation mediated by MHC class II molecules. Its use allows researchers to investigate immune responses and antigen processing pathways.
Cell Biology Studies
Due to its effect on organelle acidification, Concanamycin C is useful in studies related to intracellular trafficking, protein degradation, and other cellular processes dependent on vacuolar proton pumps.
| Molecular weight | 823.06 |
|---|---|
| Empirical formula | C45H74O13 |
| Assay | ~95% (HPLC) |
| Storage temperature | −20°C |
| Application | Cancanamycin C, a vacuolar AT Pase, is used to suppress antigen presentation by MHC class II molecules. V-ATPases are responsible for the acidification of eukaryotic organelles such as endosomes and lysosomes and the vacuoles of plants and fungi 1 |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H319Causes serious eye irritation
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P302IF ON SKIN
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3462 6.1 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28-36 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Concanamycin C used for?
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Concanamycin C is used in research for its potent inhibition of vacuolar-type H+-ATPase (V-ATPase) enzymes, aiding studies in cellular acidification, antigen presentation suppression, and various cell biology processes.
What is the CAS number and molecular formula for Concanamycin C?
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The CAS number for Concanamycin C is 81552-34-3, and its molecular formula is C45H74O13.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Concanamycin C with an assay of approximately 95% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Concanamycin C be handled safely?
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Concanamycin C is a highly toxic substance. Handling requires stringent safety measures, including the use of eyeshields, face shields, appropriate gloves, and a P3 particulate respirator filter. Avoid all routes of exposure (ingestion, skin contact, inhalation).
Is Concanamycin C shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Concanamycin C.
How can I request a quote or sample for Concanamycin C?
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Please contact our sales team via our website or directly to request a quotation or inquire about sample availability for Concanamycin C.
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