cis-4-Hydroxy-L-proline
cis-4-Hydroxy-L-proline (CAS: 618-27-9; Formula: C5H9NO3; Molar Mass: 131.13 g/mol) is a non-proteinogenic amino acid and a key building block in the synthesis of peptides and pharmaceuticals. This modified proline derivative is valued for its unique structural properties, contributing to the stability and conformation of various biomolecules. It finds application in research and development across chemical biology and synthesis.
- IUPAC
- (2S,4S)-(−)-4-Hydroxy-2-pyrrolidinecarboxylic acid,CHP

Peptide Synthesis
Utilised as a modified amino acid in the construction of peptides, influencing their structure and biological activity. It can enhance the stability of peptide chains.
Pharmaceutical Intermediates
Serves as a precursor or intermediate in the synthesis of various pharmaceutical compounds. Its chiral nature is crucial for stereoselective synthesis.
Biochemical Research
Employed in studies related to protein structure, collagen formation, and other biochemical processes where modified amino acids play a role.
Chemical Synthesis
Acts as a versatile chiral building block in organic synthesis for creating complex molecules with specific stereochemistry.
| Molecular weight | 131.13 |
|---|---|
| Empirical formula | C5H9NO3 |
| Assay | 98% |
| Grade | Vetec™ reagent grade |
| Melting point | 257 °C (dec.)(lit.) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is cis-4-Hydroxy-L-proline used for?
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cis-4-Hydroxy-L-proline is primarily used in peptide synthesis, as a pharmaceutical intermediate, in biochemical research, and as a chiral building block in chemical synthesis.
What are the CAS number and formula for cis-4-Hydroxy-L-proline?
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The CAS number is 618-27-9 and the empirical formula is C5H9NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies cis-4-Hydroxy-L-proline as Vetec™ reagent grade with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
What are the main safety concerns for cis-4-Hydroxy-L-proline?
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cis-4-Hydroxy-L-proline is classified with a WGK Germany of 3, indicating it is hazardous to water. Appropriate safety precautions should be taken during handling and storage.
How is cis-4-Hydroxy-L-proline packed and exported?
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This product is packed and exported by Tech Serve Solutions in compliance with relevant shipping regulations for chemical substances.
How can I request a sample or quote for cis-4-Hydroxy-L-proline?
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To request a sample or quote, please contact our sales team through the website or by phone, providing the product name and CAS number.
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