(−)-cis-(1S,2R)-U-50488 tartrate
(−)-cis-(1S,2R)-U-50488 tartrate (CAS: 121843-48-9) is a potent and selective kappa-opioid receptor agonist. This white solid, with a molecular weight of 519.42 g/mol, is supplied as a tartrate salt for enhanced stability and solubility. It serves as a valuable tool in neuropharmacological research, particularly for studies involving pain, addiction, and mood disorders. Its specific interaction with kappa-opioid receptors makes it a crucial reagent for investigating these complex biological pathways.
- IUPAC
- (−)-(1S,2R)-cis-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide tartrate
- Synonyms
- (−)-(1S,2R)-cis-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide tartrateU-50488 tartrate
Neuroscience Research
Utilised as a selective kappa-opioid receptor agonist to study the roles of these receptors in pain perception, analgesia, and mood regulation. It aids in understanding the neurobiological basis of conditions like depression and addiction.
Pharmacological Studies
Serves as a research chemical to investigate the downstream signaling pathways and functional consequences of kappa-opioid receptor activation. This includes exploring its effects on neurotransmitter release and neuronal excitability.
GPCR Modulation Research
A key compound for studying G protein-coupled receptors (GPCRs), specifically the OPRK1 receptor in humans. It helps elucidate the structure-activity relationships and binding kinetics of opioid receptor ligands.
| Molecular weight | 519.42 |
|---|---|
| Empirical formula | C19H26Cl2N2O · C4H6O6 |
| Form | solid |
| Colour | white |
| Solubility | ethanol: soluble |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... OPRS1(10280) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (–)-cis-(1S,2R)-U-50488 tartrate used for?
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(–)-cis-(1S,2R)-U-50488 tartrate is primarily used in scientific research as a selective kappa-opioid receptor agonist. It is valuable for studies in neuroscience, pharmacology, and cell biology, particularly for investigating pain, mood disorders, and addiction mechanisms.
What are the CAS number and formula for (–)-cis-(1S,2R)-U-50488 tartrate?
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The CAS number for (–)-cis-(1S,2R)-U-50488 tartrate is 121843-48-9. Its empirical formula is C19H26Cl2N2O · C4H6O6, and its molecular weight is 519.42 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (–)-cis-(1S,2R)-U-50488 tartrate as a research-grade chemical. The purity is not specified beyond what is typical for laboratory reagents, and TSS does not represent this product as USP, BP, or EP grade.
How should (–)-cis-(1S,2R)-U-50488 tartrate be handled safely?
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Handle (–)-cis-(1S,2R)-U-50488 tartrate with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The substance has a WGK Germany rating of 3, indicating it is hazardous to water.
How is this product shipped and stored?
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This product is supplied as a white solid and should be stored at 2-8°C. TSS adheres to all regulations for the export and shipment of laboratory chemicals.
How can I request a sample or quote for (–)-cis-(1S,2R)-U-50488 tartrate?
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To request a sample or a quote for (–)-cis-(1S,2R)-U-50488 tartrate, please contact our sales department through the website or by phone. Our team will be pleased to assist you with your research chemical needs.
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