(Chloromethyl)trimethylsilane
(Chloromethyl)trimethylsilane (CAS: 2344-80-1) is a versatile organosilicon compound with the linear formula (CH₃)₃SiCH₂Cl and a molecular weight of 122.67 g/mol. This reagent is primarily utilised in organic synthesis as a silylating agent and a source of the trimethylsilylmethyl group. It is supplied by Tech Serve Solutions as a high-purity chemical for research and development applications.
- IUPAC
- (Trimethylsilyl)methyl chloride
- Synonyms
- (Trimethylsilyl)methyl chloride
Silylating Agent
(Chloromethyl)trimethylsilane serves as an effective reagent for introducing the trimethylsilylmethyl protecting group onto various functional groups in organic synthesis. This is crucial for the temporary modification of reactive sites during multi-step syntheses.
Organometallic Synthesis
This compound is employed in the preparation of organometallic reagents, where it can be used to generate nucleophilic species for carbon-carbon bond formation. Its structure facilitates the introduction of silicon-containing moieties into complex molecules.
Chemical Synthesis Intermediate
As a reactive intermediate, (Chloromethyl)trimethylsilane is valuable in the construction of more complex organic structures. It acts as a building block in pathways leading to pharmaceuticals, agrochemicals, and advanced materials.
| Molecular weight | 122.67 |
|---|---|
| Linear formula | (CH3)3SiCH2Cl |
| Assay | 98% |
| Boiling point | 98-99 °C(lit.) |
| Density | 0.879 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.418(lit.) |
| Vapour pressure | ~25 mmHg (20 °C) |
Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -4 °C / 24.8 °F |
| Transport (UN / ADR) | UN 1993BE 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Chloromethyl)trimethylsilane used for?
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(Chloromethyl)trimethylsilane is used as a silylating agent and in organometallic synthesis for introducing the trimethylsilylmethyl group in chemical syntheses.
What are the CAS number and chemical formula for (Chloromethyl)trimethylsilane?
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The CAS number for (Chloromethyl)trimethylsilane is 2344-80-1, and its linear formula is (CH₃)₃SiCH₂Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (Chloromethyl)trimethylsilane with an assay of 98%. TSS does not represent this product as USP, BP, or EP grade.
How should (Chloromethyl)trimethylsilane be handled safely?
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(Chloromethyl)trimethylsilane is a flammable liquid and vapour (H225), causes skin irritation (H315), causes serious eye irritation (H319), and may cause respiratory irritation (H335). Always handle with appropriate personal protective equipment, including eyeshields, gloves, and use in a well-ventilated area or fume hood. Refer to the safety data sheet for full details.
How is (Chloromethyl)trimethylsilane packed, shipped, and exported?
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(Chloromethyl)trimethylsilane is packed in Sure/Seal reagents for safe handling and is shipped and exported in compliance with relevant regulations for hazardous materials, including UN 1993.
How can I request a sample or quote for (Chloromethyl)trimethylsilane?
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To request a sample or quote for (Chloromethyl)trimethylsilane, please contact the Tech Serve Solutions sales team through our website or by phone.
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