Boc-Tyr(tBu)-OH

CAS 47375-34-8(CH3)3COC6H4CH2CH(COOH)NHCOOC(CH3)3Chemical Synthesis

Boc-Tyr(tBu)-OH (CAS 47375-34-8) is a protected derivative of tyrosine, a naturally occurring amino acid. Its linear formula is (CH3)3COC6H4CH2CH(COOH)NHCOOC(CH3)3, and it has a molecular weight of 337.41. This compound is primarily utilised in peptide synthesis and chemical biology research. It serves as a crucial building block for creating complex peptides, offering protected functional groups for controlled chemical reactions.

IUPAC: Boc-O-tert-butyl-L-tyrosine
Synonyms: Boc-O-tert-butyl-L-tyrosine

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Boc-Tyr(tBu)-OH ((CH3)3COC6H4CH2CH(COOH)NHCOOC(CH3)3) — chemical structure, CAS 47375-34-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisPeptide ChemistryTyrosine

01 /Applications

Peptide Synthesis

Boc-Tyr(tBu)-OH is extensively employed as a protected amino acid in solid-phase and solution-phase peptide synthesis. The Boc (tert-butyloxycarbonyl) and tBu (tert-butyl) protecting groups allow for selective deprotection and coupling steps, facilitating the construction of peptides with specific sequences.

Chemical Biology Research

In chemical biology, this derivative is used to introduce modified tyrosine residues into peptides and proteins. This enables the study of protein function, signalling pathways, and the development of novel biomolecules.

Organic Synthesis

The compound serves as a versatile intermediate in complex organic synthesis. Its defined structure and protected functional groups make it valuable for building more intricate molecular architectures.

02 /Properties

Molecular weight	337.41
Linear formula	(CH3)3COC6H4CH2CH(COOH)NHCOOC(CH3)3
Assay	≥99.0% (sum of enantiomers, TLC)
Optical activity	[α]20/D −15.0±1.0°, c = 1% in DMF
Storage temperature	2-8°C
Melting point	113-118 °C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

47375-34-8

MDL number

MFCD00065598

Beilstein registry

4327336

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Boc-Tyr(tBu)-OH used for?

Boc-Tyr(tBu)-OH is primarily used in peptide synthesis and chemical biology research as a protected form of tyrosine.

What is the CAS number and formula for Boc-Tyr(tBu)-OH?

The CAS number is 47375-34-8, and its linear formula is (CH3)3COC6H4CH2CH(COOH)NHCOOC(CH3)3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Boc-Tyr(tBu)-OH with an assay of ≥99.0% (sum of enantiomers, TLC). This product is not represented as USP, BP, EP, or other pharmacopoeial grades.

How should Boc-Tyr(tBu)-OH be handled and stored?

Handling requires appropriate personal protective equipment, including eyeshields and gloves. The product is typically stored at 2-8°C. Refer to the Safety Data Sheet for comprehensive handling information.