Boc-Asp(OtBu)-OH

CAS 1676-90-0(CH3)3COCOCH2CH[NH(COOC(CH3)3]COOHChemical Synthesis

Boc-Asp(OtBu)-OH (CAS: 1676-90-0) is a protected derivative of aspartic acid with a molecular weight of 289.32 g/mol. Utilised in peptide synthesis, this compound features tert-butyloxycarbonyl (Boc) protection on the alpha-amino group and a tert-butyl ester on the beta-carboxyl group. These protecting groups are orthogonal and selectively removable under specific acidic conditions, facilitating complex peptide assembly. It is commonly employed in solid-phase and solution-phase peptide synthesis.

IUPAC: Boc-L-aspartic acid 4-tert-butyl ester
Synonyms: Boc-L-aspartic acid 4-tert-butyl ester

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Boc-Asp(OtBu)-OH ((CH3)3COCOCH2CH[NH(COOC(CH3)3]COOH) — chemical structure, CAS 1676-90-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesAspartic AcidChemical BiologyChemical SynthesisPeptide Chemistry

01 /Applications

Peptide Synthesis

Boc-Asp(OtBu)-OH is a crucial building block in the synthesis of peptides and peptidomimetics. Its orthogonal protecting groups allow for controlled stepwise addition of amino acids during peptide chain elongation.

Chemical Biology Research

This compound serves as a reagent in chemical biology for the preparation of modified peptides and probes. Its specific structure enables the introduction of aspartic acid residues with protected side chains into biomolecules.

Pharmaceutical Intermediate

Used in the development of novel pharmaceutical agents, Boc-Asp(OtBu)-OH acts as an intermediate in the synthesis of complex molecules with potential therapeutic applications.

Organic Synthesis

Beyond peptide chemistry, it can be employed in various organic synthesis strategies where a protected aspartic acid moiety is required for constructing complex organic structures.

02 /Properties

Molecular weight	289.32
Linear formula	(CH3)3COCOCH2CH[NH(COOC(CH3)3]COOH
Assay	≥99.0% (sum of enantiomers, TLC)
Optical activity	[α]20/D +2.0±0.4°, c = 1% in methanol
Storage temperature	2-8°C
Melting point	64-67 °C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

1676-90-0

MDL number

MFCD00076912

Beilstein registry

2336144

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Boc-Asp(OtBu)-OH used for?

Boc-Asp(OtBu)-OH is primarily used as a protected amino acid building block in peptide synthesis, chemical biology research, and as an intermediate in organic and pharmaceutical synthesis.

What are the CAS number and formula for Boc-Asp(OtBu)-OH?

The CAS number for Boc-Asp(OtBu)-OH is 1676-90-0. The linear formula is (CH3)3COCOCH2CH[NH(COOC(CH3)3]COOH.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Boc-Asp(OtBu)-OH with an assay of ≥99.0% (sum of enantiomers, TLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.

How should Boc-Asp(OtBu)-OH be handled and stored?

This compound requires careful handling. Recommended personal protective equipment includes eyeshields and gloves. For storage, maintain a temperature of 2-8°C. It is classified under WGK 2 in Germany, indicating a hazard to water.

Is Boc-Asp(OtBu)-OH a controlled substance?

The provided data does not indicate that Boc-Asp(OtBu)-OH is a controlled substance.

How is this chemical packed, shipped, and exported?

Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Specific packaging and shipping details for Boc-Asp(OtBu)-OH are available upon request, adhering to international shipping regulations.

How can I request a sample or quote for Boc-Asp(OtBu)-OH?

To request a sample or a quotation for Boc-Asp(OtBu)-OH, please contact our sales department through the website or via email, providing your specific requirements.