[Bis(trifluoroacetoxy)iodo]pentafluorobenzene

CAS 14353-88-9(CF3CO2)2IC6F5Chemical Synthesis

[Bis(trifluoroacetoxy)iodo]pentafluorobenzene (CAS: 14353-88-9) is a hypervalent iodine compound with the linear formula (CF₃CO₂)₂IC₆F₅ and a molecular weight of 519.99 g/mol. This reagent serves as a valuable tool in organic synthesis, particularly for oxidation reactions. Its applications include the oxidation of organic iodides, phenolic compounds, and amino acid derivatives, as well as oxidative cross-coupling and fragmentation reactions.

IUPAC: FPIFA,Iodopentafluorobenzene bis(trifluoroacetate)
Synonyms: FPIFAIodopentafluorobenzene bis(trifluoroacetate)

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[Bis(trifluoroacetoxy)iodo]pentafluorobenzene ((CF3CO2)2IC6F5) — chemical structure, CAS 14353-88-9; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisHypervalent IodineOxidizing AgentsSynthetic Reagents

01 /Applications

Oxidation Reactions

This compound is a reactant for the oxidation of organic iodides using oxone and trifluoroacetic acid. It also facilitates the oxidation of phenolic compounds and other organic molecules.

Coupling and Fragmentation

It is employed in oxidative cross-coupling of arenes and thiophenes, and for the oxidative fragmentation of α-amino acids or β-amino alcohols.

Aziridination

This hypervalent iodine reagent is utilised in the aziridination of alkenes, a key transformation in synthetic organic chemistry.

Base Hydrolysis

The compound can participate in base hydrolysis reactions, further broadening its synthetic utility.

02 /Properties

Molecular weight	519.99
Linear formula	(CF3CO2)2IC6F5
Assay	97%
Application	Reactant or reagent for: • Oxidation of organic iodides using oxone and trifluoroacetic acid1• Base hydrolysis2• Oxidative cross-coupling of arenes3• Oxidation of phenolic compounds with organohypervalent iodine4• Aziridination of alkenes5• Oxidation of organic compounds6• Oxidative fragmentation of α-amino acids or β-amino alcohols7• Oxidative biaryl coupling of thiophenes8
Melting point	117-119 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 1759 8 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	C
Risk statements (R)	34
Safety statements (S)	22-26-27-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

14353-88-9

MDL number

MFCD00191612

PubChem substance

24865239

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is [Bis(trifluoroacetoxy)iodo]pentafluorobenzene used for?

[Bis(trifluoroacetoxy)iodo]pentafluorobenzene is primarily used as a reagent in various oxidation reactions, including the oxidation of organic iodides, phenolic compounds, and amino acid derivatives. It is also applied in oxidative cross-coupling, fragmentation, and aziridination reactions.

What is the CAS number and formula for [Bis(trifluoroacetoxy)iodo]pentafluorobenzene?

The CAS number is 14353-88-9 and the linear formula is (CF₃CO₂)₂IC₆F₅.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies [Bis(trifluoroacetoxy)iodo]pentafluorobenzene with an assay of 97%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.

How should [Bis(trifluoroacetoxy)iodo]pentafluorobenzene be handled safely?

This compound causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection. Ensure adequate ventilation and follow emergency procedures in case of contact.

Is [Bis(trifluoroacetoxy)iodo]pentafluorobenzene shipped internationally?

Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals and can provide [Bis(trifluoroacetoxy)iodo]pentafluorobenzene worldwide.