(−)-Bis[(S)-1-phenylethyl]amine hydrochloride

CAS 40648-92-8C16H19N · HClChemical Synthesis

(−)-Bis[(S)-1-phenylethyl]amine hydrochloride (CAS: 40648-92-8; Formula: C16H19N · HCl; MW: 261.79) is a chiral amine salt utilized as a building block in asymmetric synthesis. Its specific stereochemistry makes it valuable for introducing chirality in organic molecules. This compound serves as a precursor or resolving agent in the synthesis of enantiomerically pure compounds, playing a role in the development of pharmaceuticals and fine chemicals.

IUPAC: (−)-Bis[(S)-α-methylbenzyl]amine hydrochloride

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(−)-Bis[(S)-1-phenylethyl]amine hydrochloride (C16H19N · HCl) — chemical structure, CAS 40648-92-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Amine SaltsAsymmetric SynthesisChemical SynthesisChiral Building BlocksOrganic Building Blocks

01 /Applications

Chiral Auxiliary in Asymmetric Synthesis

Serves as a chiral auxiliary to control stereochemistry during the formation of new chiral centres in organic reactions. This is crucial for the synthesis of enantiopure compounds.

Resolving Agent for Racemic Mixtures

Used to separate enantiomers from a racemic mixture by forming diastereomeric salts, which can then be separated by physical methods like crystallisation.

Precursor for Chiral Ligands and Catalysts

Can be a starting material for the synthesis of more complex chiral ligands and catalysts used in asymmetric catalysis.

Intermediate in Pharmaceutical Synthesis

Its chiral nature makes it a useful intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) where specific stereoisomers are required for efficacy.

02 /Properties

Molecular weight	261.79
Empirical formula	C16H19N · HCl
Assay	≥98.0% (AT)
Optical activity	[α]20/D −73±2°, c = 3% in ethanol
Melting point	~260 °C

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

40648-92-8

MDL number

MFCD00216671

Beilstein registry

4723969

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (–)-Bis[(S)-1-phenylethyl]amine hydrochloride primarily used for?

This compound is primarily used as a chiral building block and resolving agent in asymmetric synthesis, particularly in the development of enantiomerically pure compounds for pharmaceuticals and fine chemicals.

What is the CAS number and chemical formula?

The CAS number is 40648-92-8 and the chemical formula is C16H19N · HCl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical with an assay of ≥98.0% (AT). We do not represent it as USP, BP, EP or pharmacopoeia grade.

What are the main safety concerns when handling this compound?

This compound is a Warning irritant, causing skin (H315), eye (H319), and respiratory tract irritation (H335). Appropriate personal protective equipment including a dust mask, eyeshields, and gloves should be used.

Is this chemical suitable for export?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, pharmaceutical intermediates and laboratory reagents, and this product can be exported.