Bis(p-nitrobenzyl) phosphorochloridate
Bis(p-nitrobenzyl) phosphorochloridate (CAS: 57188-46-2; Formula: C14H12ClN2O7P) is a chemical reagent with a molecular weight of 386.68. Supplied by Tech Serve Solutions, it serves as a valuable intermediate in organic synthesis, particularly for the introduction of specific protective groups in complex molecules. Its properties make it suitable for various research and development applications within the chemical and pharmaceutical sectors.
- IUPAC
- Bis(p-nitrobenzyl)phosphoric chloride,Bis(p-nitrobenzyl) chlorophosphate,Chlorophosphoric acid bis(4-nitrobenzyl)ester
- Synonyms
- Bis(p-nitrobenzyl)phosphoric chlorideBis(p-nitrobenzyl) chlorophosphateChlorophosphoric acid bis(4-nitrobenzyl)ester

Protecting Group Chemistry
This compound is utilised for the protection of hydroxyl and amino functionalities in organic synthesis. The resulting p-nitrobenzyl groups can be selectively removed under specific conditions, facilitating multi-step syntheses.
Phosphorylation Reagent
As a phosphorochloridate derivative, it can act as a phosphorylating agent in the synthesis of phosphate esters and related compounds. This is crucial in the development of novel organophosphorus compounds.
Intermediate in Organic Synthesis
It functions as a versatile building block in the creation of more complex organic molecules. Its reactive nature allows for diverse derivatisation pathways, aiding in the development of new chemical entities.
| Molecular weight | 386.68 |
|---|---|
| Empirical formula | C14H12ClN2O7P |
| Assay | ≥98% (T) |
| Storage temperature | 2-8°C |
| Melting point | 101-108 °C |


Hazard statements
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(p-nitrobenzyl) phosphorochloridate used for?
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Bis(p-nitrobenzyl) phosphorochloridate is primarily used as a protecting group reagent in organic synthesis, particularly for hydroxyl and amino groups, and as a phosphorylating agent for creating phosphate esters.
What are the CAS number and formula for Bis(p-nitrobenzyl) phosphorochloridate?
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The CAS number is 57188-46-2 and the empirical formula is C14H12ClN2O7P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Bis(p-nitrobenzyl) phosphorochloridate with an assay of ≥98% (T). This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should Bis(p-nitrobenzyl) phosphorochloridate be handled safely?
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Danger: Causes severe skin burns and eye damage. May cause respiratory irritation. Wear protective gloves, eye protection, and face protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Ensure adequate ventilation.
How is this chemical shipped and exported?
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Tech Serve Solutions, a specialist global supplier and exporter since 1998, can arrange for the packing and export of Bis(p-nitrobenzyl) phosphorochloridate in compliance with international shipping regulations.
How can I request a sample or quote for Bis(p-nitrobenzyl) phosphorochloridate?
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To request a sample or a quote, please contact our sales department through the official Tech Serve Solutions website or by phone.
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