Biphenyl-4,4′-disulfonyl chloride
Biphenyl-4,4′-disulfonyl chloride (CAS: 3406-84-6) is a specialised organic compound with the linear formula ClSO₂C₆H₄C₆H₄SO₂Cl and a molecular weight of 351.23 g/mol. It serves as a key building block in chemical synthesis, particularly for creating complex molecules such as cyclodextrin derivatives. Its reactive sulfonyl chloride groups make it valuable for introducing the biphenyl disulfonyl moiety into various organic structures. Available from Tech Serve Solutions at 97% purity.
- Synonyms
- ClSO2C6H4C6H4SO2Cl

Synthesis of Cyclodextrin Derivatives
Biphenyl-4,4′-disulfonyl chloride has been documented for its use in the synthesis of specific cyclodextrin derivatives, such as 6<i>A</i>,6<i>D</i>-diamino-6<i>A</i>,6<i>D</i>-dideoxy-β-cyclodextrin. This highlights its utility in modifying and functionalising cyclodextrin structures for advanced applications.
Organic Synthesis Building Block
As a bifunctional sulfonyl chloride, this compound acts as a versatile building block in organic synthesis. It is employed to introduce the biphenyl-4,4′-disulfonyl core into larger molecular frameworks, facilitating the construction of diverse organic compounds.
Specialty Chemical Reagent
This reagent is valuable in research and development settings for creating novel materials and complex organic molecules. Its disulfonyl chloride functionality allows for reactions with nucleophiles, enabling the formation of sulfonamide or sulfonate ester linkages.
| Molecular weight | 351.23 |
|---|---|
| Linear formula | ClSO2C6H4C6H4SO2Cl |
| Assay | 97% |
| Application | Biphenyl-4,4′-disulfonyl chloride was used in the synthesis of 6A,6D-diamino-6A,6D-dideoxy-β-cyclodextrin1. |
| Melting point | 205-208 °C(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Biphenyl-4,4′-disulfonyl chloride used for?
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Biphenyl-4,4′-disulfonyl chloride is primarily used as a building block in organic synthesis, notably in the preparation of cyclodextrin derivatives and other complex organic molecules.
What are the CAS number and formula for Biphenyl-4,4′-disulfonyl chloride?
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The CAS number for Biphenyl-4,4′-disulfonyl chloride is 3406-84-6, and its linear formula is ClSO₂C₆H₄C₆H₄SO₂Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Biphenyl-4,4′-disulfonyl chloride with an assay of 97%. This is a technical/research grade product, and TSS does not represent it as USP, BP, EP, or pharmaceutical grade.
What are the safety and handling considerations for Biphenyl-4,4′-disulfonyl chloride?
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Biphenyl-4,4′-disulfonyl chloride is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and suitable respiratory protection, must be used. Handle only in well-ventilated areas.
How is Biphenyl-4,4′-disulfonyl chloride packed and exported?
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This compound is packed and prepared for export in compliance with international shipping regulations for hazardous materials, including UN 3261, 8/PGII classification. Please contact us for specific shipping details.
How can I request a quote or sample for Biphenyl-4,4′-disulfonyl chloride?
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To request a quote or a sample, please use the contact form on our website or call our sales team. Provide the product name and CAS number (3406-84-6) for prompt service.
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