(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate
(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (CAS: 56602-33-6, Formula: C12H22F6N6OP2) is a phosphonium-based reagent with a molecular weight of 442.28 g/mol. It is a key reagent in organic synthesis, primarily utilized for efficient peptide coupling reactions. Its applications extend to the synthesis of esters and various organic molecules, including those with potential antioxidative properties. Supplied by Tech Serve Solutions, this compound is essential for researchers and chemists in the fields of chemical biology and synthetic chemistry.
- IUPAC
- BOP Reagent,BOP,Castros reagent
Peptide Coupling Reagent
This phosphonium salt is widely employed as a coupling reagent in solid-phase and solution-phase peptide synthesis. It facilitates the formation of amide bonds with high efficiency and low racemization.
Esterification of Carboxylic Acids
The reagent is effective for the esterification of carboxylic acids. It can be used to convert carboxylic acids into their corresponding esters under mild conditions, a valuable transformation in organic synthesis.
Synthesis of Organic Molecules
It serves as a versatile reagent in the synthesis of various organic compounds, including the preparation of magnolamide, investigated for its antioxidative activity. It also acts as a catalyst in the synthesis of specific amide derivatives.
Liposome Encapsulation
This compound has been utilized in the preparation of liposomes for encapsulating plasmids, highlighting its application in advanced biochemical research and drug delivery systems.
| Molecular weight | 442.28 |
|---|---|
| Empirical formula | C12H22F6N6OP2 |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Application | Reagent for: Peptide coupling1 Synthesis of esters2 Esterification of carboxylic acids3,4 Plasmid CAN-encapsulating liposomes5 Synthesis of magnolamide for antioxidative activity6Catalyst for preparation of 9-acridinecaroboxamide derivative7 |
| Melting point | >130 °C (dec.)(lit.) |
Hazard statements
- H228Flammable solid
- H315Causes skin irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 1325 4.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | E,Xi |
| Risk statements (R) | 2-11-37/38-44 |
| Safety statements (S) | 35 |
| Supplemental hazards | Risk of explosion if heated under confinement. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate used for?
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This compound is primarily used as a reagent for peptide coupling and the synthesis of esters from carboxylic acids. It also finds applications in the synthesis of complex organic molecules and in the preparation of plasmid-encapsulating liposomes.
What are the CAS number and formula for this product?
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The CAS number is 56602-33-6 and the empirical formula (Hill notation) is C12H22F6N6OP2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety considerations when handling this chemical?
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This compound is a flammable solid (H228) and an irritant to the skin and respiratory tract (H315, H335). There is a risk of explosion if heated under confinement. Always handle with appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, and gloves, in a well-ventilated area. Store at 2-8°C. Refer to the Safety Data Sheet for full details.
How is this chemical packed, shipped, and exported?
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This product is classified under UN 1325, Hazard Class 4.1, Packing Group II, indicating it is a flammable solid. It is shipped and exported adhering to international regulations for hazardous materials.
How can I request a sample or a quote for this chemical?
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To request a sample or a quote, please contact our sales team through the website or by phone. Provide the product name and CAS number (56602-33-6) for prompt service.
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