(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (CAS: 128625-52-5) is a phosphonium-based coupling reagent with the molecular formula C18H28N6OP · PF6. It serves as a valuable alternative to BOP reagents, notably avoiding the formation of carcinogenic HMPA by-products. This compound is primarily employed in chemical synthesis, particularly in peptide chemistry, for efficient amide bond formation.
- IUPAC
- PyBOP®
Peptide Synthesis
Utilised as a coupling reagent in solid-phase and solution-phase peptide synthesis to facilitate the formation of amide bonds between amino acids and peptides. It offers an effective activation of carboxylic acids for subsequent nucleophilic attack by amines.
Amide Bond Formation
A general reagent for the synthesis of amides from carboxylic acids and amines. Its efficiency and reduced toxicity profile compared to some older reagents make it a preferred choice in synthetic organic chemistry laboratories.
Chemical Synthesis Reagent
Employed in various organic transformations requiring the activation of carboxyl groups. It is a member of the phosphonium/uronium/formamidinium class of coupling reagents.
| Molecular weight | 520.39 |
|---|---|
| Linear formula | C18H28N6OP · PF6 |
| Assay | ≥97.0% (TLC) |
| Application | Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product.1,2 |
| Melting point | ~150 °C154-156 °C (dec.)(lit.) |
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate used for?
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(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate is primarily used as a coupling reagent in peptide synthesis and general amide bond formation due to its efficiency and its advantageous avoidance of carcinogenic by-products.
What are the CAS number and formula for this compound?
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The CAS number is 128625-52-5, and the chemical formula is C18H28N6OP · PF6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of ≥97.0% (TLC). We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for this chemical?
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This compound is classified as an irritant (Xi) and poses risks of eye, respiratory, and skin irritation (36/37/38). Handle with appropriate personal protective equipment in a well-ventilated area. In case of contact, rinse eyes thoroughly with water (26) and wear suitable protective clothing (36).
Is this chemical controlled or scheduled?
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Based on the provided data, there is no indication that this chemical is controlled or scheduled.
How are Tech Serve Solutions' chemicals packed, shipped, and exported?
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Tech Serve Solutions adheres to stringent international packaging, shipping, and export regulations for all its chemicals, ensuring safe and compliant delivery worldwide.
How can I request a quote or sample for this product?
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To request a quote or sample of (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, please contact the Tech Serve Solutions sales team through our website or directly via email/phone.
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