BAPTA-AM
BAPTA-AM (CAS: 126150-97-8), a cell-permeant calcium chelator with the molecular formula C34H40N2O18 and a molecular weight of 764.68 g/mol, is a crucial tool in cellular research. It selectively binds intracellular calcium ions, modulating calcium signalling pathways. BAPTA-AM is widely employed in cell biology and neuroscience for investigating calcium's role in cell physiology, synaptic plasticity, and various cellular responses. Its ability to regulate intracellular calcium levels makes it indispensable for understanding complex biological processes.
- IUPAC
- 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)
- Synonyms
- 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)
Intracellular Calcium Chelation
BAPTA-AM is a cell-permeant ester that acts as a potent intracellular calcium chelator. It is used to reduce and buffer free intracellular calcium concentrations, allowing researchers to study the effects of calcium depletion on cellular functions.
Calcium Signaling Research
This compound is instrumental in dissecting calcium signalling pathways within cells. By controlling intracellular calcium levels, BAPTA-AM aids in understanding the downstream effects of calcium fluctuations in various cell types and biological contexts.
Cell Biology Studies
In cell biology, BAPTA-AM is applied to investigate calcium-dependent cellular processes such as cell proliferation, apoptosis, and neurotransmitter release. Its use helps to elucidate the precise role of calcium in these fundamental cellular mechanisms.
Neuroscience Research Tool
As a modulator of intracellular calcium, BAPTA-AM is valuable in neuroscience for studying calcium dynamics in neurons. This includes research into synaptic function, neuronal excitability, and calcium's involvement in neurological disorders.
| Molecular weight | 764.68 |
|---|---|
| Empirical formula | C34H40N2O18 |
| Assay | ≥98.0% (HPLC) |
| Storage temperature | −20°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is BAPTA-AM primarily used for?
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BAPTA-AM is used as a cell-permeant calcium chelator to reduce and buffer free intracellular calcium concentrations, primarily for research in cell biology, neuroscience, and calcium signaling studies.
What is the CAS number and molecular formula for BAPTA-AM?
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The CAS number for BAPTA-AM is 126150-97-8, and its molecular formula is C34H40N2O18.
What grade and purity does Tech Serve Solutions supply for BAPTA-AM?
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Tech Serve Solutions supplies BAPTA-AM with an assay of ≥98.0% (HPLC). This product is intended for research purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should BAPTA-AM be handled safely?
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BAPTA-AM is classified as a Warning with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). When handling, use a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation. Avoid breathing dust.
How is BAPTA-AM packed and shipped by TSS?
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BAPTA-AM is typically stored at −20°C. It is carefully packed and exported by TSS to maintain its stability and integrity during transit, adhering to all relevant shipping regulations for research chemicals.
How can I request a quote or sample of BAPTA-AM?
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To request a quote or sample of BAPTA-AM, please contact our sales team through the TSS website or by phone, providing your specific requirements.
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