Bafilomycin A1 from Streptomyces griseus
Bafilomycin A1 from Streptomyces griseus (CAS: 88899-55-2) is a potent antibiotic with the molecular formula C35H58O9 and a molecular weight of 622.83. This macrolide lactone is primarily recognised for its powerful inhibitory effect on V-ATPase, a key component of cellular proton pumps. Its ability to disrupt cellular acidification pathways makes it an invaluable tool in biochemical research, particularly for studying autophagy and cellular homeostasis.
Autophagy Research
Bafilomycin A1 is widely used to inhibit lysosomal degradation, making it a critical reagent for studying the mechanisms and regulation of autophagy. It blocks the fusion of autophagosomes with lysosomes, allowing researchers to investigate autophagic flux.
Cellular Acidification Studies
As a potent inhibitor of vacuolar-type H+-ATPase (V-ATPase), Bafilomycin A1 is essential for exploring the role of proton gradients in various cellular processes. This includes endocytosis, protein sorting, and organelle function.
Antiviral and Antifungal Research
While primarily known for V-ATPase inhibition, Bafilomycin A1 exhibits broad-spectrum biological activity, including antifungal properties. Its efficacy against certain viruses and fungi is an area of ongoing investigation.
Biochemical Tool
This compound serves as a valuable biochemical tool for manipulating intracellular pH and understanding the consequences of disrupting proton transport in cellular systems. Its specificity makes it useful in complex biological assays.
| Molecular weight | 622.83 |
|---|---|
| Empirical formula | C35H58O9 |
| Assay | ≥90% (HPLC) |
| Storage temperature | −20°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality Level | PREMIUM |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bafilomycin A1 primarily used for?
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Bafilomycin A1 is primarily used as a potent inhibitor of vacuolar-type H+-ATPase (V-ATPase) and for research into cellular autophagy and acidification.
What is the CAS number and formula for Bafilomycin A1?
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The CAS number for Bafilomycin A1 is 88899-55-2, and its molecular formula is C35H58O9.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Bafilomycin A1 at a PREMIUM quality level with an assay of ≥90% (HPLC). We do not represent this product as pharmacopoeia grade (e.g., USP, BP, EP).
How should Bafilomycin A1 be handled and stored?
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Handle Bafilomycin A1 with appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves. It is irritating to the skin, eyes, and respiratory tract (H315-H319-H335). Store at −20°C.
How is Bafilomycin A1 typically exported or shipped?
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Tech Serve Solutions is a global supplier and exporter of fine chemicals, shipping products worldwide according to international regulations.
How can I request a quote or sample for Bafilomycin A1?
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Please contact our sales department through the website or by phone to request a quote or inquire about sample availability.
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