Bafilomycin B1 from Streptomyces sp.
Bafilomycin B1 from Streptomyces sp. (CAS: 88899-56-3, C44H65NO13) is a toxic macrolide antibiotic with a molecular weight of 815.99 g/mol. This compound is primarily utilised in scientific research to investigate fundamental cellular processes. Its key applications include the study of autophagy, cellular pH regulation, and the intricate mechanisms underlying apoptosis. Bafilomycin B1 serves as a vital tool for researchers exploring cell biology and related disciplines.
Autophagy Research
Bafilomycin B1 is widely employed as an inhibitor of V-ATPase, a critical component in the autophagic pathway. It disrupts lysosomal acidification, thereby blocking the degradation of autophagosomal cargo and allowing researchers to study the dynamics and regulation of autophagy.
Cellular pH Studies
As an inhibitor of vacuolar-type H+-ATPase (V-ATPase), Bafilomycin B1 is instrumental in understanding the role of proton pumps in maintaining intracellular pH homeostasis across various organelles. This helps elucidate the impact of pH changes on cellular functions.
Apoptosis Mechanism Investigation
The compound aids in dissecting the complex molecular events that lead to programmed cell death. By modulating cellular pH and interfering with lysosomal function, it provides insights into the signalling cascades involved in apoptosis.
| Molecular weight | 815.99 |
|---|---|
| Empirical formula | C44H65NO13 |
| Assay | ≥80% (HPLC) |
| Storage temperature | −20°C |
| Application | Bafilomycin B1 is a toxic macrolide antibiotic used to study cell processes such as autophagy, pH control within cells, and mechanisms of apoptosis 1,2. |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P302IF ON SKIN
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3462 6.1 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28 |
| Safety statements (S) | 36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | wet ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bafilomycin B1 used for?
+
Bafilomycin B1 is primarily used in research to study cellular processes such as autophagy, cellular pH regulation, and the mechanisms of apoptosis.
What is the CAS number and formula for Bafilomycin B1?
+
The CAS number for Bafilomycin B1 is 88899-56-3, and its empirical formula is C44H65NO13.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Bafilomycin B1 with an assay of ≥80% (HPLC). We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should Bafilomycin B1 be handled safely?
+
Bafilomycin B1 is classified as Danger with hazards H300 (Fatal if swallowed), H310 (Fatal in contact with skin), and H330 (Fatal if inhaled). Appropriate personal protective equipment including eyeshields, gloves, and respiratory protection (N100 or P3 filters) is essential. Handle only in a well-ventilated area or fume hood.
How is Bafilomycin B1 shipped?
+
Bafilomycin B1 is shipped on wet ice to maintain its stability during transit.
How can I request a quote or sample?
+
To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number (88899-56-3).
▶ Related products
![(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (C8H13N3O4) — chemical structure, CAS 138472-01-2; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F138472-01-2.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
C8H13N3O4
Biochemicals & Reagents![(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide (C14H18N4O4) — chemical structure, CAS 162626-99-5; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F162626-99-5.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide
C14H18N4O4
Biochemicals & Reagents
(±)-2,5-Dimethoxy-4-bromoamphetamine hydrobromide
Biochemicals & Reagents
(±)-2-(p-Methoxyphenoxy)propionic acid
C10H12O4
Biochemicals & Reagents
(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
C10H13NO2·HBr
Biochemicals & Reagents
(±)-2-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxyoctanoic acid
C8H16O3
Biochemicals & Reagents▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis