Azidotrimethylsilane
Azidotrimethylsilane (CAS 4648-54-8), with the linear formula (CH3)3SiN3 and a molecular weight of 115.21 g/mol, is a versatile reagent for introducing the azide group. It is effectively employed in azidation reactions involving amines, amides, aldehydes, and ketones. This compound serves as a key building block in organic synthesis, facilitating C-X bond formation and finding utility in chemical biology and materials science.
- IUPAC
- Trimethylsilyl azide
- Synonyms
- Trimethylsilyl azide
Azidation of Organic Substrates
Azidotrimethylsilane is a potent azidonation reagent, efficiently converting amines, amides, aldehydes, and ketones into their corresponding azide derivatives. This process is crucial for introducing nitrogen-containing functionalities into organic molecules.
C-X Bond Formation
This silane derivative is valuable for the non-halogenated formation of C-X bonds, enabling chemists to construct complex molecular architectures. Its reactivity profile makes it a useful tool in synthetic organic chemistry.
Chemical Biology and Materials Science
The azide functionality introduced by Azidotrimethylsilane is instrumental in various chemical biology applications, including bioconjugation. It also finds use in materials science for the development of novel self-assembly materials and in micro/nanoelectronics.
| Molecular weight | 115.21 |
|---|---|
| Linear formula | (CH3)3SiN3 |
| Assay | 95% |
| Boiling point | 52-53 °C/175 mmHg(lit.) |
| Density | 0.868 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.414(lit.) |
| Storage temperature | 2-8°C |
| Application | Versatile azidonation reagent for amines,1 amides,2 aldehydes,3 and ketones.3 |
Hazard statements
- H225Highly flammable liquid and vapour
- H301Toxic if swallowed
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 6 °C / 42.8 °F |
| Transport (UN / ADR) | UN 1992 3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,T |
| Risk statements (R) | 11-23/24/25 |
| Safety statements (S) | 16-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Azidotrimethylsilane used for?
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Azidotrimethylsilane is primarily used as a versatile azidonation reagent for amines, amides, aldehydes, and ketones. It facilitates C-X bond formation and is applied in chemical biology, materials science, and organic synthesis.
What are the CAS number and formula for Azidotrimethylsilane?
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The CAS number for Azidotrimethylsilane is 4648-54-8, and its linear formula is (CH3)3SiN3.
What grade and purity does Tech Serve Solutions supply for Azidotrimethylsilane?
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Tech Serve Solutions supplies Azidotrimethylsilane with an assay of 95%. We do not represent this product as USP, BP, or EP grade.
How should Azidotrimethylsilane be handled safely?
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Azidotrimethylsilane is a highly flammable liquid and vapour (H225) and is toxic if swallowed, in contact with skin, or if inhaled (H301 + H311 + H331). It requires careful handling with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area, away from ignition sources.
How is Azidotrimethylsilane packed, shipped, and exported?
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Azidotrimethylsilane is typically stored under refrigeration (2-8°C). We ensure proper packaging and handling procedures are followed for its safe shipment and export, adhering to all relevant regulations for hazardous materials.
How can I request a quote or sample of Azidotrimethylsilane?
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To request a quote or sample of Azidotrimethylsilane, please contact our sales department through the website or by phone, providing your specific requirements.
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