Azelastine hydrochloride
Azelastine hydrochloride (CAS: 79307-93-0; Formula: C22H24ClN3O · HCl; Molar Mass: 418.36 g/mol) is a potent H1 histamine receptor antagonist and NF-kB activator. This white to off-white powder is primarily utilised in research settings to investigate therapeutic applications, such as the development of polymeric microspheres for the treatment of allergic conjunctivitis. Its bioactive small molecule nature makes it valuable in cell biology and neuroscience research.
- IUPAC
- 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one hydrochloride,Astelin,Optivar
- Synonyms
- AstelinOptivar4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one hydrochloride
Histamine Receptor Antagonism
Azelastine hydrochloride acts as a selective H1 histamine receptor antagonist. This property is fundamental to its use in research exploring the mechanisms of allergic reactions and inflammation.
NF-kB Activation Studies
As an NF-kB activator, this compound is employed in cellular studies to understand inflammatory signalling pathways. Research may focus on its role in cellular responses and immune system modulation.
Drug Discovery and Development
The compound serves as a valuable tool in drug discovery, particularly in areas related to allergic diseases and neuroinflammation. Its documented use in investigating polymeric microspheres highlights its potential in novel drug delivery systems.
Neuroscience Research
Its classification within neuroscience and neurotransmission research indicates its utility in studying neurological pathways and the function of neurotransmitters.
| Molecular weight | 418.36 |
|---|---|
| Empirical formula | C22H24ClN3O · HCl |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | −20°C |
| Application | Azelastine hydrochloride is a H1 histamine receptor antagonist and NF-kB activator. Azelastine hydrochloride has been used in a study to investigate the potential of polymeric microspheres for treatment of allergic conjunctivitis. |
Hazard statements
- H302Harmful if swallowed
| Hazard codes (EU) | Xn |
|---|---|
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Azelastine hydrochloride used for?
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Azelastine hydrochloride is used in research as an H1 histamine receptor antagonist and NF-kB activator. It has been utilised in studies investigating potential treatments for allergic conjunctivitis and in broader cell biology and neuroscience research.
What is the CAS number and chemical formula for Azelastine hydrochloride?
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The CAS number for Azelastine hydrochloride is 79307-93-0, and its chemical formula is C22H24ClN3O · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Azelastine hydrochloride with an assay of ≥98% (HPLC). This product is typically for research or technical use, and TSS does not represent it as USP, BP, or EP grade.
How should Azelastine hydrochloride be handled?
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Azelastine hydrochloride is classified as harmful if swallowed (H302). Handle with appropriate personal protective equipment, avoid ingestion, and ensure good laboratory practice. Store at −20°C.
Is Azelastine hydrochloride a controlled substance?
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The provided data does not indicate that Azelastine hydrochloride is a controlled substance.
How is Azelastine hydrochloride packed and exported?
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Azelastine hydrochloride is supplied as a white to off-white powder. Tech Serve Solutions is a global supplier and exporter, adhering to all relevant regulations for shipping chemical compounds worldwide.
How can I request a quote or sample for Azelastine hydrochloride?
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To request a quote or sample for Azelastine hydrochloride, please contact the Tech Serve Solutions sales team through our website or via direct inquiry.
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