Axitinib

CAS 319460-85-0C22H18N4OSCell Biology

Axitinib (CAS 319460-85-0) is a potent small molecule inhibitor with the empirical formula C22H18N4OS and a molecular weight of 386.47 g/mol. This compound functions as a selective inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases. It is recognised for its role in research concerning cellular signalling pathways and as a potential therapeutic agent, particularly in oncology.

IUPAC: AG-013736,N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
Synonyms: AG-013736N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide

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Axitinib (C22H18N4OS) — chemical structure, CAS 319460-85-0; Life Science, fine chemical supplied by Tech Serve Solutions

AN-AZBioactive Small MoleculesCell BiologyKinase/Phosphatase BiologyPfizer Compounds

01 /Applications

VEGF Receptor Tyrosine Kinase Inhibition

Axitinib is primarily utilized in research as a selective inhibitor of VEGF receptor tyrosine kinases. This activity makes it a valuable tool for studying angiogenesis and related cellular processes.

Oncology Research

As an approved therapeutic agent and drug candidate, Axitinib is investigated for its potential applications in cancer research. Its mechanism targets pathways critical to tumour growth and vascularization.

Bioactive Small Molecule Studies

This compound serves as a bioactive small molecule for exploring cellular biology and signalling pathways. Researchers use it to probe kinase/phosphatase biology and receptor tyrosine kinase functions.

02 /Properties

Molecular weight	386.47
Empirical formula	C22H18N4OS
Assay	≥98% (HPLC)
Form	powder
Colour	white to tan
Solubility	DMSO: ≥8 mg/mL
Storage temperature	room temp

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

GHS hazard pictogram: Environmental hazard (GHS09) — Environmental hazard

Warning

Hazard statements

H302Harmful if swallowed
H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment

Transport (UN / ADR)	UN 3077 9 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn,N
Risk statements (R)	22-50/53
Safety statements (S)	60-61

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

319460-85-0

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Axitinib used for?

Axitinib is used in research as a selective inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases, particularly in studies related to oncology and cell signalling.

What are the CAS number and formula for Axitinib?

The CAS number for Axitinib is 319460-85-0 and its empirical formula is C22H18N4OS.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Axitinib with a purity of ≥98% (HPLC). This compound is supplied for research purposes and TSS does not represent it as USP, BP, EP, or other pharmacopoeia grades.

How should Axitinib be handled?

Axitinib is classified as harmful if swallowed (H302) and very toxic to aquatic life (H400). Handle with appropriate personal protective equipment in a well-ventilated area, and avoid release to the environment (P273).

How is Axitinib packed and shipped?

Axitinib is typically supplied as a white to tan powder. It is shipped at room temperature and can be exported globally by TSS. Please consult our shipping policy for specific details.