AS-136A
AS-136A (CAS: 949898-66-2), with the molecular formula C17H19F3N4O3S and a molecular weight of 416.42, is a potent inhibitor of the measles virus (MeV) RNA-dependent RNA polymerase. Developed as part of the NIH Probes effort, this stable small molecule effectively reduces virus titer under physiological conditions. AS-136A serves as a valuable positive control in assays designed to evaluate MeV inhibitory activity, contributing to viral research.
- IUPAC
- 1-Methyl-N-[4-(1-piperidinylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide,CID 16122506,SID 24769845;
Measles Virus RNA-dependent RNA Polymerase Inhibition
AS-136A is a highly effective inhibitor of the measles virus (MeV) RNA-dependent RNA polymerase (RdRp). Its development by the NIH Probes initiative highlights its significance in antiviral research.
Antiviral Research and Assay Development
This compound is crucial for research into measles virus replication and serves as a reliable positive control in assays evaluating potential MeV inhibitory agents. It demonstrates stability and efficacy in physiological conditions.
Cell Biology and Immune System Studies
As a tool for studying viral mechanisms, AS-136A aids investigations within cell biology, particularly concerning viral infections and their impact on immune cell signaling and regulation.
| Molecular weight | 416.42 |
|---|---|
| Empirical formula | C17H19F3N4O3S |
| Assay | ≥98% (HPLC) |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | 2-8°C |
| Application | AS-136A is a small molecule developed as part of the NIH Probes effort. AS-136A is a potent measles virus (MeV) RNA-dependent RNA polymerase (RdRp) inhibitor. AS-136A is very stable, decreases virus titer after 24 hours in physiological conditions, and serves as a positive control in MeV inhibitory assays. |
Hazard statements
- H302Harmful if swallowed
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Storage Condition | desiccated |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is AS-136A primarily used for?
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AS-136A is primarily used as a potent inhibitor of the measles virus (MeV) RNA-dependent RNA polymerase (RdRp) and serves as a positive control in antiviral assays.
What is the CAS number and molecular formula for AS-136A?
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The CAS number for AS-136A is 949898-66-2, and its molecular formula is C17H19F3N4O3S.
What grade and purity does Tech Serve Solutions supply for AS-136A?
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Tech Serve Solutions supplies AS-136A with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling AS-136A?
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AS-136A is classified with GHS07 symbol and a 'Warning' signal word. It carries hazard statements H302 (Harmful if swallowed) and H319 (Causes serious eye irritation). Handle with appropriate personal protective equipment in a well-ventilated area. Ensure eyes are rinsed thoroughly if contact occurs (P305 + P351 + P338).
How is AS-136A typically stored and shipped?
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AS-136A should be stored at 2-8°C in a desiccated state. Tech Serve Solutions exports chemicals globally, adhering to all necessary shipping regulations.
How can I request a quote or sample for AS-136A?
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To request a quote or a sample of AS-136A, please contact our sales team through the website or by direct inquiry, providing your details and requirements.
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