Ansamitocin P-3 from Actinosynnema pretiosum
Ansamitocin P-3 (CAS: 66584-72-3) is a macrocyclic lactone belonging to the ansamycin family, with the chemical formula C32H43ClN2O9 and a molecular weight of 635.14 g/mol. Derived from *Actinosynnema pretiosum*, this compound is recognised for its potent biological activity, particularly as a microtubule-targeting agent. It serves as a valuable research tool in cell biology and cancer research, aiding investigations into cellular processes and drug discovery.
Microtubule Inhibition Research
Ansamitocin P-3 acts as a potent inhibitor of microtubule polymerization. This makes it an essential reagent for researchers studying the dynamics of the cytoskeleton, cell division (mitosis), and intracellular transport mechanisms.
Cell Biology Studies
As a bioactive small molecule, Ansamitocin P-3 is utilised in cell biology laboratories to investigate cellular responses to microtubule disruption. Its specific mechanism of action allows for precise studies in cell cycle regulation and apoptosis.
Drug Discovery and Development
The cytotoxic properties of Ansamitocin P-3 make it a compound of interest in preclinical drug discovery. It can serve as a lead compound or a research probe for developing novel anti-cancer therapeutics targeting tubulin.
Cell Signaling Investigations
Researchers in cell signaling pathways, particularly those involving the cytoskeleton or neuronal function, may use Ansamitocin P-3 to modulate cellular responses and elucidate complex signaling cascades.
| Molecular weight | 635.14 |
|---|---|
| Empirical formula | C32H43ClN2O9 |
| Assay | ≥90% (HPLC) |
| Storage temperature | 2-8°C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ansamitocin P-3 used for?
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Ansamitocin P-3 is used as a research tool in cell biology, particularly for studying microtubule dynamics, cell division, and as a probe in drug discovery, especially for anti-cancer therapeutics.
What are the CAS number and chemical formula for Ansamitocin P-3?
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The CAS number for Ansamitocin P-3 is 66584-72-3, and its chemical formula is C32H43ClN2O9.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ansamitocin P-3 with an assay of ≥90% as determined by HPLC. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Ansamitocin P-3 be handled?
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Ansamitocin P-3 is a Warning substance (H302, H315, H319, H332, H335). Handle with appropriate personal protective equipment including a dust mask (type N95 US recommended), eyeshields, and gloves. Avoid inhalation and contact with skin and eyes. Ensure adequate ventilation.
How is Ansamitocin P-3 stored and shipped?
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Ansamitocin P-3 should be stored at 2-8°C. Tech Serve Solutions exports this chemical globally, adhering to all necessary regulations for safe transport.
How can I request a sample or quote for Ansamitocin P-3?
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To request a sample or a quote for Ansamitocin P-3, please contact our sales team through the website or by phone, providing your specific requirements.
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