ANA-12
ANA-12 (CAS: 219766-25-3), with the chemical formula C22H21N3O3S and a molecular weight of 407.49 g/mol, is a research chemical primarily used as a TrkB inhibitor. Supplied as a white to beige powder, it is soluble in DMSO. This compound is a valuable tool in cell biology, particularly for studies involving cell signaling, neuroscience, and neurotrophic factors, aiding in the investigation of kinase pathways.
- IUPAC
- N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide
TrkB Inhibition in Neuronal Studies
ANA-12 has been employed to selectively inhibit the Tropomyosin receptor kinase B (TrkB) in experimental settings. This application is crucial for researchers investigating the role of TrkB signalling in neuronal function and development.
Cellular Signalling Research
As a tool compound, ANA-12 is utilised in cell biology laboratories to explore pathways regulated by TrkB. Its use helps elucidate the downstream effects of TrkB activation or inhibition in various cell types.
Neuroscience Research
The compound is valuable in neuroscience research for studying neurotrophic factor signalling and its impact on neuronal survival, differentiation, and plasticity. Studies have used ANA-12 in primary rodent neuronal cultures.
| Molecular weight | 407.49 |
|---|---|
| Empirical formula | C22H21N3O3S |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to beige |
| Solubility | DMSO: ≥5 mg/mL at 60 °C |
| Storage temperature | 2-8°C |
| Application | ANA-12 was used to inhibit TrkB in primary mouse cortical neurons1 and primary rat hippocampal cultures.2 |
Hazard statements
- H302Harmful if swallowed
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is ANA-12 used for?
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ANA-12 is primarily used as a TrkB inhibitor in research settings, particularly in neuroscience and cell biology to study cellular signalling pathways.
What is the CAS number and chemical formula for ANA-12?
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The CAS number for ANA-12 is 219766-25-3, and its chemical formula is C22H21N3O3S.
What grade and purity does Tech Serve Solutions supply for ANA-12?
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Tech Serve Solutions supplies ANA-12 with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
What are the safety and handling considerations for ANA-12?
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ANA-12 is classified with GHS07 symbol and a 'Warning' signal word, carrying the hazard statement H302 (Harmful if swallowed). Handle with appropriate personal protective equipment, avoiding ingestion. Refer to the Safety Data Sheet for detailed information.
How is ANA-12 shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. ANA-12 is carefully packed and exported according to international shipping regulations for chemical compounds.
How can I request a sample or quote for ANA-12?
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To request a sample or a quotation for ANA-12, please contact our sales team via the website or by phone. Please specify the required quantity and your shipping destination.
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