AP-18
AP-18 (CAS: 55224-94-7), with the molecular formula C11H12ClNO and a molecular weight of 209.67 g/mol, is a selective TRPA1 channel blocker. This compound is recognised for its ability to reduce chronic pain associated with arthritis by inhibiting transient receptor potential ankyrin 1 receptors. AP-18 has demonstrated efficacy in reducing nociception <i>in vivo</i> and reversing mechanical hyperalgesia in mice, while also blocking specific cold- and mustard oil-induced TRPA1 activations.
- IUPAC
- 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
TRPA1 Channel Blockade
AP-18 functions as a selective blocker of the transient receptor potential ankyrin 1 (TRPA1) channels. This mechanism of action is crucial for investigating TRPA1 channel function in various physiological and pathological processes.
Pain Research
This compound is instrumental in research for chronic pain conditions, particularly those linked to arthritis. Its ability to reduce nociception and mechanical hyperalgesia in preclinical models makes it a valuable tool for studying pain pathways.
Neuroscience Research
AP-18 is utilised in cell signaling and neuroscience research due to its interaction with ion channels. It helps in understanding the role of TRPA1 channels in neuronal excitability and sensory transduction.
Cell Biology Studies
As a modulator of voltage-gated ion channels, AP-18 aids in cell biology studies by allowing researchers to probe the function and regulation of TRPA1 channels within cellular systems.
| Molecular weight | 209.67 |
|---|---|
| Empirical formula | C11H12ClNO |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | white to off-white |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | 2-8°C |
| Application | AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is AP-18 used for?
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AP-18 is used as a selective TRPA1 channel blocker in research, particularly for studying chronic pain associated with arthritis, as well as in cell biology and neuroscience.
What are the CAS number and molecular formula for AP-18?
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The CAS number for AP-18 is 55224-94-7, and its molecular formula is C11H12ClNO.
What grade and purity does Tech Serve Solutions supply for AP-18?
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Tech Serve Solutions supplies AP-18 with a purity of ≥98% (HPLC). This product is intended for research purposes and is not supplied as USP, BP, or EP grade.
How should AP-18 be handled safely?
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AP-18 is classified as harmful if swallowed (H302). When handling, it is recommended to use a dust mask type N95 (US), eyeshields, faceshields, and gloves to minimise exposure.
How is AP-18 shipped and exported?
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AP-18 is stored at 2-8°C. Tech Serve Solutions, as a specialist global supplier and exporter, can arrange for the shipment and export of AP-18 worldwide, adhering to all relevant regulations.
How can I request a quote or sample for AP-18?
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To request a quote or a sample of AP-18, please contact our sales team through the website or by phone.
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