(±)Amethopterin hydrate
(±)Amethopterin hydrate (CAS 60388-53-6 (anhydrous)), molecular formula C20H22N8O5 · xH2O, is a high-purity chemical supplied by Tech Serve Solutions for biochemicals & reagents applications, to pharmacopoeia specification (USP, BP, EP). Every batch is tested and ships with a Certificate of Analysis; MSDS and technical data sheets are available on request. Tech Serve Solutions has supplied laboratory reagents, fine chemicals and pharmaceutical intermediates worldwide since 1998.
- IUPAC
- 4-Amino-10-methylfolic acid,DL-4-Amino-N10-methylpteroylglutamic acid,MTX,Methylaminopterin
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| Molecular weight | 454.44 (anhydrous basis) |
|---|---|
| Empirical formula | C20H22N8O5 · xH2O |
| Assay | ≥95% |
| Form | powder |
| Colour | yellow to yellow with an orange cast |
| Solubility | H2O: insolubleNaOH: soluble (minimal amount of 0.1 N NaOH to solubilize, then dilute in neutral buffer or saline) |
| Storage temperature | −20°C |
| Application | Amethopterin is a folic acid antagonist and potent anticancer agent. Amethopterin blocks DNA synthesis by preventing the production of tetrahydrofolate cofactors which are required to make thymidine. Amethopterin is actively transported into cells by the folate transporter where it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, a dihydrofolate reductase inhibitor. |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H360May damage fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P301IF SWALLOWED
- P305IF IN EYES
- P308IF exposed or concerned
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1544 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 61-25-36/38 |
| Safety statements (S) | 53-26-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... DHFRP1(573971), FPGS(2356), SLC19A1(6573), TYMS(7298)mouse ... Dhfr(13361)rat ... Dhfr(24312) |
|---|
Documentation
Supplied to USP, BP and EP standards. Every batch ships with a Certificate of Analysis (assay, identity, purity); MSDS and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (±)Amethopterin hydrate?
+
(±)Amethopterin hydrate (CAS 60388-53-6 (anhydrous)), molecular formula C20H22N8O5 · xH2O, is a high-purity chemical supplied by Tech Serve Solutions for biochemicals & reagents applications, to USP, BP and EP standards.
What grades of (±)Amethopterin hydrate does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (±)Amethopterin hydrate in USP, BP, EP and reagent/AR grades. Custom specifications for nutraceutical or specialty pharmaceutical applications are available — contact our technical sales team.
What is the CAS number and molecular formula of (±)Amethopterin hydrate?
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(±)Amethopterin hydrate has CAS number 60388-53-6 (anhydrous) and molecular formula C20H22N8O5 · xH2O. Full specifications appear in the table above and in the Certificate of Analysis.
What is the typical minimum order quantity and lead time for (±)Amethopterin hydrate?
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Sample quantities are available for technical evaluation; bulk MOQ depends on grade and packaging. In-stock material typically ships in 7–10 working days; custom-spec orders take 3–4 weeks. Tech Serve Solutions ships worldwide with full export documentation.
Do you provide a Certificate of Analysis (CoA) with each shipment?
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Yes. Every batch of (±)Amethopterin hydrate ships with a Certificate of Analysis covering assay, identity and purity tests, plus pharmacopoeia conformance where applicable. MSDS and TDS documents are available on request before order placement.
How should (±)Amethopterin hydrate be stored?
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Store (±)Amethopterin hydrate in its original sealed container in a cool, dry place away from direct sunlight and incompatible materials, in line with the storage guidance on the Safety Data Sheet. Reseal between dispensings.
What is (±)Amethopterin hydrate used for?
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(±)Amethopterin hydrate is used in biochemicals & reagents applications across pharmaceutical, research and industrial settings. Our technical team can advise on suitability for your specific process.
How do I request a quote for (±)Amethopterin hydrate?
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Request a quote with your required grade, quantity and destination via https://www.techservesolutions.in/contact or email info@techservesolutions.in. We respond with specifications, a Certificate of Analysis and pricing.
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