β-Amanitin from Amanita phalloides
β-Amanitin from Amanita phalloides (CAS: 21150-22-1) is a highly toxic cyclic peptide, a potent inhibitor of RNA polymerase II. With the molecular formula C39H53N9O15S and a molecular weight of 919.95 g/mol, this compound is crucial for research into transcription, gene regulation, and cell signaling. It is isolated from the death cap mushroom and serves as a vital tool for biochemists and molecular biologists studying eukaryotic transcription processes.
Inhibition of RNA Polymerase II
β-Amanitin is a specific and powerful inhibitor of eukaryotic RNA polymerase II, making it an indispensable tool for studying transcription initiation, elongation, and regulation in molecular biology research.
Research in Cell Biology
Its ability to block transcription makes β-Amanitin valuable for investigating cellular processes dependent on gene expression and for understanding the mechanisms of cell death and survival pathways.
Tool for Neuroscience Studies
This compound aids in the study of cell signaling pathways and neuronal function by allowing researchers to precisely control gene transcription in experimental models.
Biochemical Research
As a well-characterized toxin, β-Amanitin is used to probe the structure and function of RNA polymerases and to develop assays for drug discovery targeting transcription.
| Molecular weight | 919.95 |
|---|---|
| Empirical formula | C39H53N9O15S |
| Assay | ~90% (HPLC) |
| Storage temperature | −20°C |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P302IF ON SKIN
- P310Immediately call a POISON CENTER or doctor
| Transport (UN / ADR) | UN 3462 6.1 / PGI |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28 |
| Safety statements (S) | 7-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is β-Amanitin from Amanita phalloides used for?
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β-Amanitin is primarily used as a potent inhibitor of eukaryotic RNA polymerase II in biochemical and cell biology research, aiding studies in transcription, gene regulation, and cell signaling.
What is the CAS number and formula for β-Amanitin?
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The CAS number for β-Amanitin is 21150-22-1, and its molecular formula is C39H53N9O15S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies β-Amanitin with an assay of ~90% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling precautions for β-Amanitin?
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β-Amanitin is extremely toxic. It carries GHS hazard statements H300 (Fatal if swallowed), H310 (Fatal in contact with skin), and H330 (Fatal if inhaled). Handle with extreme caution in a controlled environment, using appropriate personal protective equipment (gloves, lab coat, eye protection) and engineering controls (fume hood). P260, P264, P280, P284, P302 + P350, P310.
How is β-Amanitin shipped and exported?
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This product is shipped and exported according to relevant international regulations for hazardous materials, identified as UN 3462, Class 6.1, Packing Group I.
How can I request a sample or quote for β-Amanitin?
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To request a sample or a quote for β-Amanitin, please contact our sales team through the Tech Serve Solutions website or by calling our customer service number.
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