AM580
AM580 (CAS: 102121-60-8), with the molecular formula C22H25NO3 and a molecular weight of 351.44 g/mol, is a synthetic retinoid derivative. It is primarily utilised in biological research for its role in studying gene expression, particularly concerning the differentiation of leukemia-retinoic acid receptor (PHL-RAR) cell lines. This compound serves as a valuable tool for investigating cellular signalling pathways and gene regulation mechanisms.
- IUPAC
- 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid
Gene Expression Studies
AM580 is employed in research to investigate the effects of retinoid derivatives on gene expression patterns, specifically in cell lines like the PHL-RAR, which are crucial for understanding leukemia differentiation processes.
Cellular Differentiation Research
As a retinoid derivative, AM580 is used to probe the mechanisms of cellular differentiation, providing insights into how specific signalling pathways regulate cell fate and development.
PPAR and RXR Pathway Investigation
This compound is relevant for studies focusing on Peroxisome Proliferator-Activated Receptors (PPAR) and Retinoid X Receptors (RXR), as retinoids are known modulators of these nuclear receptors involved in metabolism and gene regulation.
| Molecular weight | 351.44 |
|---|---|
| Empirical formula | C22H25NO3 |
| Assay | ≥98% (TLC) |
| Storage temperature | −20°C |
| Application | Retinoid derivative used for gene expression studies of leukemia-retinoic acid receptor (PHL-RAR) cell line differentiation. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... RARA(5914), RARB(5915) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is AM580 used for?
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AM580 is used in research for studying gene expression, particularly the differentiation of leukemia-retinoic acid receptor (PHL-RAR) cell lines, and for investigating cellular signalling and gene regulation.
What is the CAS number and formula for AM580?
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The CAS number for AM580 is 102121-60-8, and its molecular formula is C22H25NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies AM580 with a purity of ≥98% (TLC). We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for AM580?
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Handle AM580 with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Refer to the safety data sheet for comprehensive handling information. The WGK Germany is 3.
How is AM580 typically supplied or shipped?
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AM580 is stored at -20°C and is carefully packaged for domestic and international export by Tech Serve Solutions.
How can I request a sample or quote for AM580?
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To request a sample or a quotation for AM580, please contact the Tech Serve Solutions sales team through our website or by direct inquiry.
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