Alendronate sodium trihydrate
Alendronate sodium trihydrate (CAS: 121268-17-5) is a white powder with a molecular weight of 325.12 g/mol. This compound acts as a potent inhibitor of bone resorption, farnesyl diphosphate synthase, and the CD45 protein tyrosine phosphatase. It is utilised in research settings for its biochemical properties and potential applications in areas related to bone metabolism and cellular signalling.
- IUPAC
- 4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium,MK-217
- Synonyms
- 4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium
Bone Resorption Inhibition
Alendronate sodium trihydrate is recognised for its efficacy in inhibiting bone resorption, a process critical in maintaining bone health and treating conditions like osteoporosis. Its mechanism involves interfering with osteoclast activity.
Enzyme Inhibition Research
This compound serves as a valuable tool in biochemical research due to its inhibitory effects on farnesyl diphosphate synthase and CD45 protein tyrosine phosphatase. These targets are relevant in various cellular processes and disease states.
Cellular Signalling Studies
As a modulator of cellular pathways, alendronate sodium trihydrate is employed in studies investigating cell signalling, particularly those involving lipids and kinase regulation. Its effects on mevalonate pathways are of particular interest in cancer research.
| Molecular weight | 325.12 |
|---|---|
| Empirical formula | C4H12NaNO7P2 · 3 H2O |
| Assay | ≥97% (NMR) |
| Form | powder |
| Colour | white |
| Solubility | water, double-distilled: soluble10 mg/mL |
| Storage temperature | −20°C |
| Application | Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Alendronate sodium trihydrate used for?
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Alendronate sodium trihydrate is used as a research chemical for its properties as a bone resorption inhibitor, a farnesyl diphosphate synthase inhibitor, and a CD45 protein tyrosine phosphatase inhibitor. It is also used in studies of cancer metabolism, cell biology, and cell signalling.
What is the CAS number and formula for Alendronate sodium trihydrate?
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The CAS number is 121268-17-5. The empirical formula (Hill notation) is C4H12NaNO7P2 · 3 H2O.
What grade and purity does Tech Serve Solutions supply for Alendronate sodium trihydrate?
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Tech Serve Solutions supplies Alendronate sodium trihydrate with an assay of ≥97% as determined by NMR. This product is intended for research and laboratory use and is not represented as USP, BP, or EP grade.
How should Alendronate sodium trihydrate be handled safely?
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Alendronate sodium trihydrate is classified as harmful if swallowed (H302) and requires careful handling. Recommended personal protective equipment includes a dust mask (type N95), eyeshields, and gloves. It is assigned a WGK rating of 3 in Germany, indicating it is hazardous to water.
Is Alendronate sodium trihydrate packed, shipped, or exported globally by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Alendronate sodium trihydrate. We offer various pack sizes to meet research and development needs.
How can I request a quote or sample of Alendronate sodium trihydrate?
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To request a quote or a sample of Alendronate sodium trihydrate, please visit the product page on our website or contact our sales team directly. We will be pleased to assist you.
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