Adenosine 5′-[γ-thio]triphosphate tetralithium salt
Adenosine 5′-[γ-thio]triphosphate tetralithium salt (CAS: 93839-89-5), with the formula C10H12Li4N5O12P3S, is a non-hydrolysed ATP analogue. This biochemical reagent is invaluable for studying ATP binding in various processes, including extracellular functions. It acts as a P2 purinergic agonist and can substitute for ATP in kinase reactions, producing thiophosphorylated proteins resistant to phosphatases. Its molecular weight is 546.98 g/mol.
- IUPAC
- ATP-γ-S,Adenosine 5′-(3-thiotriphosphate) tetralithium salt,Ado-5′-PPP[S]
- Synonyms
- ATP-γ-S,Adenosine 5′-(3-thiotriphosphate) tetralithium salt,Ado-5′-PPP[S]
![Adenosine 5′-[γ-thio]triphosphate tetralithium salt (C10H12Li4N5O12P3S) — chemical structure, CAS 93839-89-5; Life Science, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F93839-89-5.png&w=3840&q=75)
ATP Binding Studies
Utilised as a non-hydrolysed analogue to investigate the effects of ATP binding in diverse biological processes, particularly extracellular functions and ATP-dependent steps in protein modification.
Enzyme Kinetics and Kinase Assays
Serves as a substrate in kinase reactions, yielding thiophosphorylated proteins that are resistant to protein phosphatases, enabling detailed studies of enzyme mechanisms.
Ion Channel Modulation
Acts as a P2 purinergic agonist, demonstrating utility in research focused on the activity of Ca2+-activated K+ channels.
Proteasome Research
Modulates ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome, aiding research into protein degradation pathways.
Cellular Signalling Research
Differentiates Toll-like receptor 4-mediated cell survival and death pathways, offering insights into immune and inflammatory responses.
| Molecular weight | 546.98 |
|---|---|
| Empirical formula | C10H12Li4N5O12P3S |
| Assay | ≥75% |
| Form | powder |
| Colour | white |
| Solubility | H2O: soluble25 mg/mL |
| Storage temperature | −20°C |
| Application | Adenosine 5′-[γ-thio]triphosphate (ATP-γ-S) is widely used as a non-hydrolyzed ATP analogue for studies on the effects of ATP binding to ATP sites in a wide range of processes including extracellular functions. ATP- γ-S is a P2 purinergic agonist which increases the activity of Ca2+-activated K+ channels. ATP- γ-S can substitute for ATP in kinase reactions yielding thiophosphorylated proteins that are resistant to protein phosphatases and modulate the ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome. ATP-γ -S differentially modulates Toll-like receptor 4-mediated cell survival and death. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | dry ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Adenosine 5′-[γ-thio]triphosphate tetralithium salt used for?
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Adenosine 5′-[γ-thio]triphosphate tetralithium salt is used as a non-hydrolysed ATP analogue for studying ATP binding in various processes, including extracellular functions. It also acts as a P2 purinergic agonist and can be used in kinase reactions to produce thiophosphorylated proteins.
What are the CAS number and formula for Adenosine 5′-[γ-thio]triphosphate tetralithium salt?
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The CAS number is 93839-89-5 and the empirical formula is C10H12Li4N5O12P3S.
What grade and purity does Tech Serve Solutions supply for Adenosine 5′-[γ-thio]triphosphate tetralithium salt?
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Tech Serve Solutions supplies Adenosine 5′-[γ-thio]triphosphate tetralithium salt with an assay of ≥75%. This product is intended for research purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should Adenosine 5′-[γ-thio]triphosphate tetralithium salt be handled safely?
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Handle Adenosine 5′-[γ-thio]triphosphate tetralithium salt with appropriate personal protective equipment, including a dust mask (N95 US type), eyeshields, and gloves. Avoid inhalation of dust and ensure adequate ventilation. Refer to the safety data sheet for comprehensive handling information.
How is Adenosine 5′-[γ-thio]triphosphate tetralithium salt shipped?
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Adenosine 5′-[γ-thio]triphosphate tetralithium salt is shipped on dry ice to maintain its stability during transit.
How can I request a quote or sample?
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To request a quote or a sample of Adenosine 5′-[γ-thio]triphosphate tetralithium salt, please contact our sales team via the website or by telephone.
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