Adenosine 2′,5′-diphosphate sodium salt
Adenosine 2′,5′-diphosphate sodium salt (CAS: 154146-84-6) is a crucial biochemical reagent with a molecular weight of 427.20 (free acid basis). This compound serves as a competitive antagonist for P2Y1 receptors and a non-selective antagonist of the platelet P2X1 ion channel, making it valuable for studying these cellular components. It is also employed in the preparation of affinity chromatography matrices for enzyme purification.
- IUPAC
- 2′-Phosphoadenosine 5′-phosphate sodium salt
- Synonyms
- 2′-Phosphoadenosine 5′-phosphate sodium salt
P2Y1 Receptor Antagonism Studies
Adenosine 2′,5′-diphosphate sodium salt acts as a competitive antagonist of the P2Y1 receptor. This property allows researchers to investigate the physiological roles and signaling pathways associated with P2Y1 receptor activation.
P2X1 Ion Channel Research
This compound functions as a non-selective antagonist of the platelet P2X1 ion channel. Its use helps in understanding the mechanisms and functions of this ion channel, particularly in platelet aggregation and related processes.
Affinity Chromatography Preparation
Adenosine 2′,5′-diphosphate can be immobilised onto agarose to create an affinity matrix. This specialised matrix is used for the purification of enzymes, such as NADPH-cytochrome P450 reductase and glutathione reductase, which interact with the diphosphate moiety.
| Molecular weight | 427.20 (free acid basis) |
|---|---|
| Empirical formula | C10H15N5O10P2 · xNa+ |
| Assay | ≥95% |
| Storage temperature | −20°C |
| Application | Adenosine 2′,5′-diphosphate is a competitive antagonist of P2Y1 receptor and a non-selective antagonist of the platelet P2X1 ion channel and it may be used to study the mechanisms and activities of these components. Adenosine 2′,5′-diphosphate may be used to prepare adenosine 2′,5′-diphosphate agarose for affinity chromatography purification of enzymes such as NADPH-cytochrome P450 reductase and glutathione reductase. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Adenosine 2′,5′-diphosphate sodium salt used for?
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Adenosine 2′,5′-diphosphate sodium salt is used as a competitive antagonist of P2Y1 receptors and a non-selective antagonist of the platelet P2X1 ion channel for studying their mechanisms and activities. It is also used to prepare adenosine 2′,5′-diphosphate agarose for affinity chromatography purification of enzymes like NADPH-cytochrome P450 reductase and glutathione reductase.
What are the CAS number and molecular formula for Adenosine 2′,5′-diphosphate sodium salt?
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The CAS number is 154146-84-6. The empirical formula is C10H15N5O10P2 · xNa+.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Adenosine 2′,5′-diphosphate sodium salt with an assay of ≥95%. TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated.
How should Adenosine 2′,5′-diphosphate sodium salt be handled and stored?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The product should be stored at -20°C. For German environmental classification, it has a WGK of 3.
Is Adenosine 2′,5′-diphosphate sodium salt a controlled substance?
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The provided data does not indicate that Adenosine 2′,5′-diphosphate sodium salt is a controlled substance.
How is this product packed, shipped, and exported?
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Products are typically packed securely for transport and exported globally by TSS according to international shipping regulations for chemical compounds. Specific packaging details are available upon request.
How can I request a sample or quote for Adenosine 2′,5′-diphosphate sodium salt?
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Please contact our sales team or use the online enquiry form on our website to request a sample or a quotation for Adenosine 2′,5′-diphosphate sodium salt.
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